Analysis Of TCM Syndrome Types Of Subacute Thyroiditis And Inflammatory Factors And Related Factors

Objective:To explore the different regular of TCM syndromes of Subacute thyroiditis(SAT),through analyzing the relationship between the syndrome types and inflammatory factors and some related factors.Methods:Divided the 15 0 patients into five types:heat toxin prosperity syndrome,liver stagnation-fire syndrome,yin deficiency and fire prosperity syndrome,qi stagnation-phlegm obstruction syndrome,spleen-kidney yang weakness syndrome.At last,collected the information of patient’s,thyroid-related indexes and inflammatory factors-related indexes,then analyzed the correlation among medical syndromes,thyroid-related indexes and inflammatory factors.Results:1.The regular of types was as following:heat toxin prosperity syndrome(3 2%)>liver stagnation-fire syndrome(22%)>qi stagnation-phlegm obstruction syndrome(1 8%)>yin deficiency and fire prosperity syndrome(16.67%)>spleen-kidney yang deficiency syndrome(11.3 3%).There were more female patients than male patients,and there was no statistically difference in gender and age in the five TCM syndromes(P>0.05).And there was statistical significance in disease course,temperature,pulse,heart rate,TSH,FT3,FT4,TRAb,ESR,CRP and inflammatory factors among different TCM syndrome types(P<0.05).2.Related analysis showed that the IL-3 was correlated with disease course,TSH,pulse,FTs,FT4,and ESR(r=0.084,0.2,-0.05 1,-0.08 1,-0.181,-0.077,P<0.05);IL-6 was correlated with the disease course,TSH,temperature,heart rate,pulse,FTs,FT4,TRAb,ESR and CRP(r=-0.225,-0.141,0.095,0.084,0.05,0.23 1,0.158,0.036,0.169,0.123,P<0.05);TNF-α was correlated with disease course,TSH,temperature,heart rate,pulse,FT3,FT4,TRAb,ESR and CRP(r=-0.288,-0.476,0.227,0.055,0.224,0.526,0.078,0.208,0.1 18,P<0.05).3.The results of regression analysis shows that there is a correlation(P<0.05)between the heat toxin stagnation syndrome and the course of disease,CRP,FT3,ESR,and IL-6(P<0.05).The incidence ratios are 0.809,0.929,1.100,1.120,1.302,and the rest of the indicators are no correlation with the heat toxin prosperity syndrome;the liver stagnation-fire syndrome is correlated with the course of disease,FT4,CRP,and TNF-α(P<0.05),the incidence ratios are 1.076,1.236,1.090,1.022,and the other indicators are no correlation;Yin deficiency and fire prosperity syndrome is correlated with TSH,ESR,FT4,and IL-6(P<0.05),and the incidence ratios are 0.690,0.916,1.026,1.1 84,and other indicators are no correlation;Qi stagnation-phlegm obstruction syndrome is related to TSH,FTs,FT4,and IL-3,and the incidence ratios are 1.347,0.593,0.880,0.95 1.The other indicators are no related to the Qi stagnation and phlegm ob st ruction syndrome.Spleen-kidney yang deficiency syndrome is correlated with TRAb and ESR(P<0.05),the incidence is 0.095,0.888,and other indicators have no correlation with spleen-kidney yang deficiency syndrome.Conclusion:1.In the 15 0 cases of SAT patients,the number of heat toxin stagnation syndrome is the most,liver depression transforms fire syndrome second,spleen and kidney yang deficiency syndrome is the least,yin deficiency fire prosperous syndrome and qi depression phlegm block syndrome have the similar number of cases.2.The comparison of TNF-α,IL-6,IL-3,ESR,CRP and TSH,FTs,FT4,TRAb among the 5 TCM syndrome types has obvious differences.3.The IL-6 of the five TCM syndromes of the syndrome of heat poisoning and prosperity is higher than that of the other syndromes,the TNF-α of the liver depression and fire syndrome is higher than that of the other syndromes,and the IL-3 of the spleen and kidney yang deficiency syndrome is higher than other card types.4.SAT’s syndrome of heat toxin stagnation and yin deficiency and fire prosperous syndrome are positively correlated with IL-6,liver-stagnation transforming fire syndrome is positively correlated with TNF-α,and qi stagnation and phlegm block syndrome is negatively correlated with IL-3.