| Research purposes: based on intestinal mucosal immune from lung)to illustrate Ma Xing Shi gan decoction enema therapy on children with pneumonia asthma intervention approaches of lung-intestinal microenvironment and inner link,and further reveals the mechanism of the curative effect of traditional Chinese medicine enema therapy to treat pneumonia asthma,and to explore its in the lungs-intestinal mucosal immune system and regulating role in intestinal flora distribution and the inner link,for the traditional Chinese medicine "lung intestinal development" ideas to provide experimental basis and new treatment idea,promote the traditional Chinese medicine therapy of promotion.Research methods: this research is divided into clinical research and experimental research,clinical research object for pneumonia asthma infants and young children,by random grouping,divided into Ma Xing Shi sweet soup high concentration group of 34 cases,low concentration group of 34 cases,34 cases of western medicine group.High concentrations of Chinese traditional medicine group with a low dose(3 ml/kg)Ma Xing Shi gan decoction enema symptomatic treatment is given priority to,traditional Chinese medicine(TCM)low concentration group with high dose(5 ml/kg)Ma Xing Shi gan decoction enema symptomatic treatment is given priority to,western medicine group is given priority to with symptomatic treatment enema physiological saline.Test before treatment,enema 3,7 days after the end of each group with change of target bacteria in the intestine,respiratory s Ig A and been secreted in the saliva and fecal calcium protein changes before and after the treatment,and observed before and after treatment in children with total score as well as the primary symptom of TCM syndromes was single the change of the integral,and use SPASS24.0 statistical software for statistical analysis.Experimental study to establish the rat model with viral pneumonia,divided into high and low dose Ma Xing Shi sweet soup enema group and model group,through rat alveolar lavage s Ig A and been,fecal calcium protein and s Ig A and defensive element content and observation analysis.The experiment done by two people together,my whole journey to participate in the experiment,and by collecting children and rat droppings,analysis before and after treatment in children with intestinal flora of clubs than change and rats before and after treatment of fecal s Ig A and defense element changes.Research results: The clinical research part of this project included a total of 120 eligible cases,12 cases dropped,102 completed cases,34 cases in the high concentration group of Chinese medicine,34 cases in the low concentration group of Chinese medicine,34 cases in the control group,and the first three treatment groups There was no statistical difference in gender,age,total scores of TCM syndromes,individual scores of main symptoms,and clubto-ball ratios,and they were comparable.In the experimental part,the fecal s Ig A and defensin of the three groups of rats before treatment were not statistically different,and they were comparable.1.he overall curative effectThere is no difference in the effective rate of the three groups after treatment,but the high-concentration group is better than the low-concentration group and the western medicine group,and the three groups have been tested,P=0.022<0.05,there are statistics Learn meaning.After pairwise comparison,the high-concentration group and the western medicine group(P=0.01)were statistically significant;the low-concentration group was compared with the high-concentration group and the western medicine group,respectively,P<0.05,which was not statistically significant.2.Clinical symptom efficacy analysisAfter 3 days of treatment,the results of the comparison within the group showed that the high concentration of Chinese medicine showed the fastest effect,followed by the low concentration of Chinese medicine group,and the western medicine group was the slowest.The total scores of TCM syndromes: the total scores of the three groups after treatment were significantly lower than those before the treatment,P<0.01,there was a significant statistical difference,suggesting that the treatments of the three groups are all effective.After treatment,the total score of the three groups was compared,P<0.01,which was statistically significant,indicating that the Chinese medicine enema plus symptomatic treatmentThe total scores of TCM syndromes: The total scores of TCM syndromes after treatment in the three groups were all significantly lower than before treatment,P<0.01,which was statistically significant,indicating that the treatments in the three groups had definite curative effects.After treatment,the total scores of the three groups were compared.The western medicine group had the lowest score,followed by the low-concentration group,and the highconcentration group was the lowest,P<0.01,which was statistically significant,indicating that TCM enema plus symptomatic treatment was better than the control group in improving the disease in children.TCM scores for main symptoms: After treatment,the three groups of TCM scores for the main symptoms were compared.The P value of the three groups of children’s fever and wheeze scores was greater than 0.05,which was not statistically significant,indicating that the three groups did not improve both fever and wheeze.difference.The P values of the scores of cough,phlegm,lung signs were all less than 0.05,which was significant.A post-hoc comparison of the significance level corrected by Bonferroni’s method.In terms of cough improvement,the three group were compared with each other respectively(P<0.05),There were statistical differences,suggesting Chinese medicine Enema has a definite effect on improving children’s cough;in terms of improving phlegm,the high-concentration Chinese medicine group is compared with the rest of the two group respectively(P<0.05),there is a statistical difference,the low-concentration group is compared with the western medicine group(P=1.000),there is no statistical difference,suggesting that Chinese medicine enema has a definite effect on improving children’s phlegm,and if the child’s physical condition allows,the effect of Chinese medicine enema with high concentration is better than that of Chinese medicine with low concentration enema;in improving the lungs In terms of physical signs,there was no statistically significant difference between the high-concentration Chinese medicine group and the low-concentration Chinese medicine group(P=1.000 after adjustment),the difference between the high-concentration Chinese medicine group and the western medicine group(P<0.05)was statistically significant,and the low-concentration Chinese medicine group The difference between the group and the western medicine group(P<0.05)was statistically significant,suggesting that the traditional Chinese medicine enema has a definite effect on improving the lung signs of children,which is better than the symptomatic treatment with western medicine alone.3.Analysis of the experimental indicators:the club-to-club ratio :after treatment of the three groups of children was lower than that before treatment,P<0.05.After treatment,the ratios of the three groups of clubs to clubs were significantly different,suggesting that the three groups are effective in improving the children.Cue ratio has curative effect.After the Bonferroni method corrected the significance level of the post-hoc comparison,the high concentration group and the low concentration group were compared with the western medicine group(P<0.05),which was statistically significant;the high concentration group and the low concentration group(P= 1.000),there is no statistical significance,and the cue to club ratio of the three groups of intestinal flora before treatment is 2/8-8/2,and the cue to club ratio of the high concentration group of Chinese medicine after treatment is 1/9-3/7.The low-concentration cue-to-club ratio is distributed between 1/9-4/6,and the cue-to-club ratio of the western medicine group is distributed between 2/8-7/3.treatment.In the experimental part of this project,a total of 60 SD male rats aged 4-5 weeks were selected from the same batch,weighing 150g±50g.Among them,20 rats were in the highdose Chinese medicine group,20 were in the low-dose Chinese medicine group,and 20 were in the control group.The fecal s Ig A and defensin of the three groups of rats before treatment were not statistically different,and they were comparable.(1)Defensins: intra-group comparison: P<0.05 before and after treatment in the highconcentration group,which is statistically significant;the P value before and after treatment in the low-concentration group and the model group is greater than 0.05,which is not statistically significant;comparison between groups: P after treatment in the three groups<0.05,there is a statistical difference.After the Bonferroni method was used to adjust the significance level,there was a statistical difference between the high concentration group and the western medicine group(P=0.000 after adjustment),the low concentration group and the western medicine group(P=0.008);there was a statistical difference between the high concentration group and the western medicine group(P=0.008 after adjustment).In the low concentration group(P=0.58 after adjustment),there was no statistical difference.It indicates that Maxing Shigan Decoction is effective in treating mice with pneumonia.(2)SIgA: The SIgA of the high concentration group of traditional Chinese medicine and the low concentration group of traditional Chinese medicine were both higher than before treatment,both P<0.05,which was statistically significant,suggesting that the traditional Chinese medicine enema has a significant effect on improving intestinal SIgA.Analysis conclusion:This topic is applied to children with pneumonia,asthma and cough,and the efficacy is compared with the control group and the conclusion is drawn:1.In terms of alleviating TCM syndromes in children,symptomatic treatment of TCM high concentration group,TCM low concentration group and Western medicine group can effectively improve the symptoms of children,but the overall efficacy of TCM high concentration group is significantly better than TCM low concentration group And the western medicine group;the low-concentration Chinese medicine group is better than the western medicine group;Chinese medicine enema plus western medicine symptomatic treatment has the fastest effect in improving the symptoms of children.2.Chinese medicine enema therapy can promote the secretion of SIgA by regulating the intestinal flora to achieve the purpose of intervening in the treatment of pneumonia in the pulmonary-gut axis.The enema has a definite effect in the treatment of children with pneumonia,asthma and cough,and the children’s family and children have high compliance and are worthy of clinical application. |
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