| Objective:To observe and explore the clinical efficacy of the treatment of blood-heat psoriasis by adding/subtracting Liangxue Huoxue decoction decoction combined with auricular-plaster therapy,and to provide objective basis by observing the changes under dermoscope,so as to explore an effective treatment method for the traditional Chinese medicine treatment of blood heat psoriasis.Methods:All the 61 patients included in the final clinical study were selected from the patients with blood-heat psoriasis who were treated in the dermatology department of Anhui Hospital of Traditional Chinese Medicine from December 2019 to December2020.They were divided into groups by simple sequencing randomization method,including 31 patients in the treatment group and 30 patients in the control group.The treatment group was treated by adding and subtracting Liangxue Huoxue Decoction orally combined with auricular-plaster therapy;The control group was given compound glycyrrhizin tablet orally.Topical capotriol cream was used in all patients and treated for8 weeks.PASI score,pruritus score,TCM syndrome score,dermatosis quality of life index,dermoscopic changes and adverse reactions of the two groups before and after treatment were observed and recorded.Statistical methods were used for comparative analysis.Results:1.Comparison of PASI score,TCM syndrome score,itching degree score and DLQI score: there was no statistical difference in the four scores between the two groups before treatment((49)>0.05),indicating comparability.Within the two groups,the improvement was more obvious at the end of 4 and 8 weeks than before treatment((49)<0.01);At the end of 4 weeks of treatment,there were no significant differences in PASI score and DLQI score between the two groups((49)>0.05),while there were significant differences in TCM symptom score and pruritus score between the two groups((49)<0.05).The improvement of PASI score,TCM syndrome score,pruritus score and DLQI score in the treatment group were better than those in the control group at the end of 8 weeks((49)<0.05).2.Comparison of clinical efficacy: the total effective rate of the treatment group was 54.83%,and that of the control group was 43.33%,with no statistical difference((49)>0.05).The efficacy of the two groups was similar.After 8 weeks of treatment,the total effective rate of the treatment group was 93.54%,and that of the control group was86.67%,with statistical difference((49)<0.05).The treatment group was superior to the control group.3.Correlation between PASI score and DLQI before treatment: Spearman rank correlation analysis showed r=0.158,(49)=0.222((49)>0.05),and there was no statistical difference or significant correlation between the two.4.Comparison of dermoscopic performance scores: there was no difference between the two groups before treatment((49)>0.05),which was comparable;Compared with before treatment,both groups were improved at the end of 4 and 8 weeks((49)<0.01).There was no statistical difference between the two groups after 4 weeks of treatment((49)>0.05),and the improvement in the treatment group was better than that in the control group after 8 weeks of treatment((49)<0.05).5.Adverse reactions: 1 patient in both groups suffered from mild discomfort during the treatment,and the symptoms disappeared after treatment,indicating that the safety of the treatment method adopted in this study was acceptable.Conclusion:The treatment of blood-heat psoriasis by adding and adding/subtracting Liangxue Huoxue decoction combined with auricular-plaster therapy has considerable curative effect,which can better improve the skin lesions and itching degree of patients,improve the quality of life of patients with low side effects and good safety.Dermatoscopy,as a commonly used auxiliary examination tool for dermatological diseases,has good clinical significance in disease diagnosis,observation and evaluation of efficacy,and is worthy of further study with good prospects. |
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