Effects Of Obstructive Sleep Apnea On Sleep And Cognitive Function In Patients With Schizophrenia Under Cardiopulmonary Coupling Analysis

Background Cognitive impairment is an important feature of schizophrenia.Obstructive sleep apnea syndrome(OSAS)not only affects sleep quality,but also has extensive cognitive impairment.The incidence of OSAS in patients with schizophrenia is relatively high,and further affects the sleep and cognitive function of patients with schizophrenia.However,there are few studies on sleep and cognitive impairment of OSAS in schizophrenic population.Objective Patients with schizophrenia have sleep and cognitive impairment,and often combined with obstructive sleep apnea.This study compared sleep situation and cognitive function in schizophrenia patients comorbidity with or no with obstructive sleep apnea.This study aims to explore the obstructive sleep apnea in patients with schizophrenia and the influence of cognitive function.Methods From March 2018 to December 2019,patients with schizophrenia hospitalized in the Department of Psychiatry,Chaohu Hospital,Anhui Medical University were recorded by cardiopulmonary coupling analysis technique.The RBANS scale was used to evaluate the patients’ cognitive function,and the Epworth sleepiness scale and PANSS scale were used to evaluate the patients’ daytime sleepiness and psychotic symptoms.Healthy people who were examined in the physical examination center of our hospital during the same period were selected as the control group.Results A total of 80 hospitalized patients with schizophrenia and 31 healthy controls were enrolled.According to sleep apnea index(AHI)≥ 5 times/h,patients were divided into the obstructive sleep apnea syndrome(OSAS)group and the group without OSAS.There were statistically significant differences between the three groups in the total score of RBANS and the scores of immediate memories,visual breadth,speech function,attention and delayed memory.Compared with the group without OSAS,the group with OSAS had more severe impairments in visual breadth,speech function,delayed memory,and total score of RBANS(all P values <0.01).In terms of sleep monitoring indicators,the OSAS group had shorter sleep time,longer light sleep time,longer awakening time,and higher AHI values(all P values <0.01).The total score of RBANS and its factors were negatively correlated with AHI,course of disease,and negative symptom scores(all P <0.05).Speech function,total score of RBANS were negatively correlated with light sleep time and wake-up time(all P <0.05),speech function,Attention was negatively correlated with age(P <0.05).Multiple regression analysis showed that AHI,disease course,and years of education were related to the cognitive function of patients.Conclusion Cognitive impairment was more severe in schizophrenia with obstructive sleep apnea,and AHI,course of disease,and years of education were associated with cognitive function in schizophrenia.Obstructive sleep apnea is an important factor affecting sleep and cognitive function in patients with schizophrenia.Early detection of sleep breathing in patients with schizophrenia and timely intervention can reduce sleep and cognitive impairment caused by obstructive sleep apnea.