| Part 1 The influencing factors of non-organic anorexia in childrenObjective: To improve parents’ cognition of children’s non-organic anorexia and reduce the incidence of children’s non-organic anorexia through the study of influencing factors.Methods: The 122 children aged 1 to 6 in the children healthcare clinic and pediatric clinic of our hospital were the research subjects,among which 61 children with non-organic anorexia were set as experimental groups,and 61 children undergoing the healthy physical examination were set as the control groups.Uniform questionnaire were completed by the families of the children,of which survey items include: general situation,delivery way,whether born at term,infant feeding pattern,add complementary food monthly age,eating mode,the meal time,whether to chase or coax to feed,picky or partial eating,snack intake,temperament type,hemoglobin,trace elements,family economy status,feeding people’s educational level,educational methods,feeding methods and parenting knowledge,etc.The collected data were analyzed by single-factor analysis and multi-factor logistic analysis with statistical differences in single-factor analysis results.Results:Among the 61 children with non-organic anorexia,there were 33 males and 28 females,age(3.19 ±1.12)years old,weight(13.05±2.10)kg,height(93.48±9.51)cm,Body mass index(BMI)(14.97±1.13)kg/m.2There were 11 cases with mild,6 cases with moderate and 2 cases with severe protein-energy malnutrition,9 cases with developmental retardation,and 4 cases with developmental retardation and malnutrition,respectively.There were 13 cases of zinc deficiency and 9 cases of nutritional iron deficiency anemia.Among the 61 healthy children,there were 35 males and 26 females,aged(3.18±1.21)years old,weight(15.09±2.67)kg,height(98.26±9.54)cm,BMI(15.57±0.93)kg/m.2The gender and age of children in the two groups were not statistically significant(P>0.05),that is,the experimental group and the control group were comparable.After statistical analysis,the BMI of children with non-organic anorexia was lower than that of healthy control group(P<0.05).Univariate analysis showed that Non-organic children anorexia were affected by temperament type,infant feeding pattern,add complementary food monthly age,the meal time,whether to chase or coax to feed,picky or partial eating,snack intake,temperament type,hemoglobin,trace elements,feeding crowd,feeding people’s educational level,educational methods,whether forced feeding and parenting knowledge that 14 factors,Among them,difficult temperament,artificial feeding,adding supplementary food late,eating time ≥40min,chasing the feed(coax to feed),picky or partial eating,excessive intake of snacks,reduced hemoglobin and zinc and iron content,grandparents feeding,without parenting knowledge,low education level,beating and abusing,forced eating are the risk factors of anorexia in children.Among 61 cases of anorexia children,the proportions of each risk factor from high to low were without parenting knowledge(81.97%),forced feeding(57.38%),chasing or coaxing feeding(55.74%),eating time ≥40min(54.10%),beating and scolding(47.54%),artificial feeding(44.26%).Grandparent feeding(44.26%),excessive intake of snacks(40.98%),primary school education or below(40.98%),picky or partial eating(37.70%),and difficult temperament(34.43%).The children with anorexia were taken as the dependent variable,and the 14 influencing factors in univariate analysis(P<0.05)were taken as the independent variable.Multivariate Logistic regression analysis showed that the later the complementary food is added,and the longer feeding time were the independent risk factors for non-organic anorexia,and the prevalence of anorexia increased by 6.9 times for every 1 month delay in the addition of complementary food.Conclusion: 1.Non-organic anorexia in children is affected by many factors,and the later the complementary food is added,and the longer feeding time were the independent risk factors for non-organic anorexia in children.2.Not partial to food or picky about food,scientific feeding,early and timely add complementary food,do not spoil children,through patience,praise and encourage children to eat,to create a good eating environment for children,can reduce the prevalence of children’s non-organic anorexia.Part 2 The study on serum brain-gut peptides of non-organic anorexia in childrenObjective: To investigate the relationship between serum cerebrointestinal peptide level and anorexia in children with non-organic anorexia and its clinical significance,so as to lay a foundation for further research on the pathogenesis of anorexia.Methods:The second part includes children who can collect serum specimens in the first part,of them,32 children with non-organic anorexia as experimental groups,the 35 children with normal physical examination as control groups.And the levels of serum Gastrin(GAS),Motilin(MTL),β-endorphins(β-EP),Leptin(Lp),Vascularactive intestinal peptide(VIP)and Cholecystokinin(CCK)were detected by ELISA method.Results: ELISA showed that the levels of GAS,MTL and β-EP in children with non-anorexia were lower than those in normal children(P<0.05),and the levels of LP,VIP and CCK were higher than those in normal children(P<0.05).Conclusion: There is a disturbance in the secretion of serum brain-gut peptide in children with non-organic anorexia,and the change of brain-gut peptide may be closely related to the occurrence of anorexia. |
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