Risk Factors Analysis Of Patients With Non-valvular Atrial Fibrillation In Qinghai Area

Objective: Combined with the clinical characteristics of patients with NVAF,this paper analyzed the risk factors related to the occurrence and development of NVAF in Qinghai,and understood the risk factors and associated diseases of patients with NVAF in Qinghai,so as to provide some reference for the prevention and treatment of atrial fibrillation.Methods: A total of 680 patients admitted to the Affiliated Hospital of Qinghai University and diagnosed with nonvalvular atrial fibrillation from January2018 to October 2020 were selected as the case group,includng 336 patients in paroxysmal atrial fibrillatin group and 344 patients diagnosed with non-paroxysmal atrial fibrillation.During the same period,216 healthy people without atrial fibrillation were collected as the control group.Clinical data of all subjects were collected and recorded,including related comorbidities,general information,laboratory indicators and cardiac ultrasound indicators.Results:1.Compared with the general basic information of the healthy control group,there was no statistical significance in gender distribution and age composition between the two groups(P > 0.05),but there was statistical significance in body mass index(BMI)and smoking history(P<0.05);Test to compare two groups in triglyceride(TG)and hemoglobin(Hb)have no statistical significance(p > 0.05),while in fasting plasma glucose,serum uric acid(UA),total cholesterol(TCH),C(inhibition(Cys-C),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),blood homocysteine(HCY),red blood cells deposited(HCT)was statistically significant(p<0.05);There were significant differences in left atrial inner diameter(LAD),left ventricular end-diastolic inner diameter(LVEDD),left ventricular end-diastolic volume(EDV)and left ventricular ejection fraction(LVEF)between the two groups(P < 0.05).2.The results of binary multivariate Logistic regression analysis of the occurrence of nonvalvular atrial fibrillation indicated that high blood glucose,high Hcy,high Cys-C,increased LAD,and increased EDV were risk factors for the occurrence of nonvalvular atrial fibrillation.3.Compared with the general basic information between thenon-paroxysmal atrial fibrillation group and the paroxysmal atrial fibrillation group,there was no statistical significance in gender composition,previous smoking history and BMI between the two groups(P > 0.05),but there was statistical significance in age(P < 0.05).The proportions of chronic bronchitis,COPD,pulmonary heart disease,coronary heart disease,hypertension,diabetes and heart failure in the combination of non-paroxysmal atrial fibrillation were significantly higher than those in the paroxysmal atrial fibrillation group,with statistical significance(P < 0.05).The levels of TCH and LDL-C in the paroxysmal atrial fibrillation group were higher than those in the non-paroxysmal atrial fibrillation group,while the levels of UA and Hcy were lower than those in the non-paroxysmal atrial fibrillation group,the differences among groups were statistically significant(P< 0.05),and the comparison of other indicators among groups showed no statistical significance(P > 0.05).Comparison of cardiac ultrasound indicators showed that LAD level in paroxysmal atrial fibrillation group was lower than that in non-paroxysmal atrial fibrillation group,while LVEDD,EDV and LVEF levels were higher than those in non-paroxysmal atrial fibrillation group,with statistical significance in all indicators(P < 0.05).4.Binary Logistic regression analysis of the factors for the further development of NVAF indicated that the age,HCY and LAD were higher in the group with NVAF than in the group with NVAF,and they were risk factors for the aggravation of NVAF.Conclusion:1.Risk factors for NVAF in qinghai area may include: hyperglycemia,high Hcy,high Cys-C,increased LAD,and increased EDV.2.In patients with non-valvular atrial fibrillation,the level of HDL-C is low,which may decrease the anti-inflammatory effect of the body,thus aggravating the remodeling of atrium and ventricle,increasing the levels of LAD,LVEDD and EDV,decreasing LVEF,and decreasing cardiac systolic function.3.In the development of NVAF,the increase of age,Hcy and LAD may be the risk factors for the aggravation of NVAF.