| Objective:To investigate the relationship between the occurrence of IMH and choroidal thickness and sex hormone levelsMethod:Forty one IMH patients who were eligible for inclusion were collected from May15,2020,to January 20,2021,diagnosed in the Department of Ophthalmology of our hospital,including 36 patients with unilateral IMH（24 females,12 males）,18 with right eye,18 with left eye,and 5 patients with bilateral IMH（4 females,1 male）.A total of 41 eyes of unilateral IMH affected eye and the right eye of bilateral IMH patients were set as the experimental group,and 30 patients with simple senile cataract diagnosed in our hospital during the same period,including 12 males and 18females.A total of 30 eyes from the right eyes of simple senile cataract patients were set as the control group.All patients were recruited preoperatively with relevant medical history,such as gender,age,and previous medical history,and underwent preoperative relevant examinations,such as visual acuity,intraocular pressure,slit lamp examination,axial measurement,B-ultrasound of both eyes and optical coherence tomography,which were clearly diagnosed by the same chief physician,and all patients passed the inclusion and exclusion criteria.Choroidal thickness was measured in all patients using EDI OCT at 8 a.m,at the fovea（SFCT）and 1 mm,2mm from the fovea superior,inferior,temporal,and nasal to the fovea,while the size of the foveal base diameter was measured in patients with IMH,and changes in choroidal thickness were recorded and analyzed in all subjects.At the same time,3ml of elbow vein blood was drawn from all patients in the early morning fasting state,centrifuged at rest,and the supernatant was taken for measurement of gonadal hormone levels by chemiluminescence method in all patients,which was recorded and analyzed between choroidal thickness and gonadal hormone levels.Result:1.IMH and sex hormone levelsE2:the E2 of male in IMH group was 37.11±7.14pg/ml,and that of control group was 46.36±11.75pg/ml,the difference was statistically significant（t=-2.40,P=0.02<0.05）;the E2of female in IMH group was lower than that of control group,the difference was not statistically significant（P=0.63>0.05）.T:T=17.31±7.34ng/dl in female IMH group and 23.48±9.04ng/dl in control group,the difference was statistically significant（t=-2.53,P=0.02<0.05）;testosterone in male IMH group was lower than that in control group,the difference was not statistically significant（P=0.90>0.05）.Serum levels of follicle stimulating hormone（FSH）,luteinizing hormone（LH）and prolactin（PRL）were not statistically different between the two groups2.IMH and choroidal thicknessThe SFCT=176.96±49.73μm in the affected eyes of IMH patients was significantly lower than that in the control eyes SFCT=239.91±46.05μm（t=-5.25,P=0.001）,and the choroidal thickness in IMH affected eyes at 1mm,2mm from the fovea superior,inferior,temporal,and nasal to the fovea was significantly lower than that in control eyes（P<0.05）.Correlation analysis of IMH,SFCT and sex hormone levels1)The single factor analysis:IMH was significantly negatively correlated with estradiol in males and testosterone in females,SFCT was positively correlated with estradiol in males,no correlation with other sex hormone levels,and negative correlation with age and axial length in females.2)The multivariate regression analysis:IMH was significantly correlated with SFCT（OR=0.962,95%Cl:0.942-0.982,P=0.001）and significantly negatively correlated with estradiol in males and testosterone in females（OR=0.895,95%Cl:0.038-0.805,P=0.038;and OR=0.896,95%Cl:0.046-0.804,P=0.046）,while SFCT was not correlated with sex hormone levels and was independently correlated with age or axial length.Conclusion:1.The decrease in choroidal thickness is an independent risk factor for IMH;2.Estradiol and testosterone levels in serum may be risk factors for the development of IMH;3.there was no significant correlation between choroid thickness and gonadal hormone levels in serum,and was independent of age and axial length. |
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