| Background and Objective:Febrile seizures(FS)is the commonest type of seizure in children and22.7～32%of children with FS would relapse.The purpose of our study was to company efficacy of antipyretics in preventing FS recurrence at different temperature and to identify the risk factors for recurrence of FS.Methods:From July 1,2019 to December 31,2019,232 children with FS(including simple FS and complex FS)admitted in the Department of Neurology of Jiangxi Children’s Hospital were enrolled,who all met the diagnostic criteria,the inclusion criteria and exclusion criteria.They were randomly divided into experimental group whereas there were 118 cases and control group whereas there were 114 cases.The children in the experimental group took ibuprofen when the axillary temperature was≥38°C within 72 hours after the onset of fever.If the body temperature didn’t drop or continue to rise in One hour after the medication,acetaminophen could be given orally.Given that necessary,acetaminophen could be administered repeatedly at 4 hour intervals,or ibuprofen at 6 hour intervals.When the axillary temperature of children in the control group is≥38.5℃,the same antipyretic protocol was adopted.All children were followed up for 12 months.The content of the follow-up included the episodes of fevers and FS recurrences,seizure type,the body temperature at the time of seizures,adverse drug reactions(rash/urticaria/granulocytopenia/liver and kidney damage,etc.),the times of taking antipyretics and the causes for dropouts.The recurrence rate and recurrence rate cases between the two groups were compared,and the preventive effect of antipyretics taken in different temperatures on FS was compared.The risk factors for FS recurrence were investigated by multivariate analysis.Results:(1)The recurrence rate and the recurrence rate cases were 21.05%and 15.31%respectively in experimental group;whereas 19.64%and 12.62%in the control group.There were no staistical differences(?~2=0.07,P=0.79;?~2=0.62,P=0.43).(2)The monofactor analysis indicated that<11 months began at age,family history of seizures,cesarean section,gastroenteritis symptoms,fever frequency≥3episodes in 1 year were related to the recurrence of FS.(3)The age at onset,family history of seizures,mode of delivery,and gastroenteritis symptoms were analyzed by the multivariate analysis.Logistic regression analysis demonstrated that family history of seizures,cesarean section,gastroenteritis symptoms were independent risk factors for recurrence of FS(P<0.05),and that the family history of seizures(Wald=9.62)was the most influenced factor for the recurrence of FS and cesarean section and gastroenteritis symptoms took second and third places.Conclusions:(1)There is no difference in the efficacy of antipyretics employed in preventing FS recurrence at different temperature.(2)The possible risk factors of FS recurrence included male,<11 months of onset,family history of seizure,cesarean section,gastroenteritis,fever frequency≥3episodes,abnormal MRI of head.(3)The independent risk factors of FS recurrence were family history of seizure,cesarean section,gastroenteritis symptoms,and family history of seizure had the most obvious effect,followed by the remaining factors.(4)The recurrence rate of FS increased with the increase of risk factors. |
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