A Clinical Analysis Of106Cases Of Childhood Febrile Seizures

Objective: Using retrospective study to analyze the detailed data of106chinldren with febrile seizures, to investigate the clinical characteristics ofchildren with febrile seizures and offer some clinical experience in treatment andprognosis of patients with febrile seizures.Methods: In this descriptive retrospective study,106children with febrileseizures,admitted between May2007and October2011in the First Hospital ofguangxi Medical University, were collected and followed, all of them weredefinitely diagnosed febrile seizures. We mainly analysed the patients’characteristics,i.e., age of on set, sex, cause of fever, type of seizure,temperature of seizure, duration of seizure, recurs within24hours,electroencephalograms(EEGs),neural imaging examination， family history,treatment of febrile seizures patients,and examine the correlation between thesecharacteristics and recurrence or prognosis of febrile seizures;Analyzeretrospectively and summarize these clinical data by SPSS13.0software,and generalize a conclusion from the data．Result:1、A group of124children met all entry criteria. However,18children were excluded since no follow-up information could be obtainedafter the initial evaluation. This report is, therefore, based on the remaining106children for those are followed for a median of27months (range6-58months).Children with febrile seizres were usually12months to3years of age,the peak occurrence is in children12to18months of age. The ratio between thetwo sexes was75boys and31girls (2.42:1).2、Of the106patients with the first febrile seizures, a total of87(82.1%)had had a simple and19(17.9%) a complex febrile seizure. Some31（29.2%）had temperatures between38and38.5℃when seizure occurred,60children（56.6%）between38.6and39.9℃，and15children（14.2%）40℃or more.Atotal of98(92.5%) had had a short lasting (less than15minutes) and25(7.5%) along lasting (15minutes or more) seizure. In74cases (69.8%) febrile seizuresoccurred within12hours of fever,6cases (5.7%) within12-24hours of fever, in2(1.9%) seizures occurs after24hours of fever and24cases (22.6%) had feverafter1hour of seizure. The most common types of diseases were respiratorytract infections in96children (90.6%), and upper respiratory tract infections in64children (60.4%), others were diarrheas, vaccinations, roseola infantums,sinusitis.3、Recurrent febrile seizures occurred in70of the106children (66%) with a cumulative risk of82.9%at one year and94.3%at two years.There were threefactors, namely early age at onset (<15months), duration longer than15minand seizure occurring before or within1hour of fever duration at the first febrileseizures were risk factors for febrile seizures（P<0.05）. Sex, type of seizures,temperatures, recurs within24hours, cause of fever, positive family history offebrile seizure in the first degree relatives, positive family history of epilepsy inthe second degree relatives, neurologic deficits or developmental delay, neuralimaging examination results, and electroencephalogram results of the firstfebrile seizure were not risk factors for recurrent febrile seizures.The incidenceof epilepsy in this study was3.8%and the incidence of febrile seizure plus was5.7%.4、No significant differences among antipyretic treatment during febrileillnesses, intermittent prophylaxis,continuous prophylaxis（P>0.05）.Conclusion：1、Children with febrile seizres were more likely in boys,and were usually12months to3years of age, the peak occurrence is in children12to18monthsof age. Respiratory tract infections are the most frequent cause of febrileseizures.2、In this study,There were four factors, namely early age at onset (<15months), duration longer than15min and seizure occurring before or within1hour of fever duration at the first febrile seizures were risk factors for febrileseizures.Sex, type of seizures, temperatures, recurs within24hours, cause of fever, positive family history of febrile seizure in the first degree relatives,positive family history of epilepsy in the second degree relatives, neurologicdeficits or developmental delay, neural imaging examination results, andelectroencephalogram results of the first febrile seizure were not risk factors forrecurrent febrile seizures.3、In most cases, febrile seizures were benign and posed a low risk ofprogression to epilepsy,and few developed febrile seizure plus.