Correlation Study On Glucose And Lipid Metabolism And Pancreatic β-cell Function In New Type 2 Diabetes With Intestinal Damp-heat Syndrome And Liver-stomach Stagnation Heat Syndrome

Objective: To study the relationship between glucose and lipid metabolism of intestinal damp-heat syndrome and liver-gastric stagnation-heat syndrome and pancreatic β-cell function in newly diagnosed type 2 diabetes,and to explore the relationship between glucose and lipid metabolism and pancreatic β-cell function in these two TCM syndromes.Provide a theoretical basis for early intervention and treatment of type 2 diabetes patients.Methods: Select the first-onset patients from the Department of Endocrinology of the Affiliated Hospital of Gansu University of Traditional Chinese Medicine or admitted to the hospital and meet the diagnostic criteria of type 2 diabetes for four-diagnosis of TCM syndrome differentiation.Select 30 patients with intestinal damp-heat syndrome and 30 patients with liver-stomach stagnation syndrome,and record the age and course of disease.,Height,weight,and calculate body mass index(BMI)and other general items,while fasting blood glucose(FBG),2 hours postprandial blood glucose(2hPBG),glycosylated hemoglobin(HbA1c),blood lipids(TC,TG,HDL-C,LDL)-C),fasting insulin + C peptide(FINs + CP),2h insulin + C peptide determination(2hFINs + 2hC-P),calculate the insulin resistance index(HOMA-IR),insulin secretion index(HOMA-β),and Compare the different changes of liver and stomach stagnation-heat syndrome and intestinal damp-heat syndrome in the above indicators,explore the relationship between glucose and lipid metabolism and insulin β-cell function of the two TCM syndrome types,and use SPSS20.0 statistical software for data analysis,select multi-class Logistic The regression analysis method analyzes the correlation between the glucose and lipid metabolism of the two TCM syndromes and the function of insulin β-cells.Results:1.Intestinal damp-heat syndrome was compared with liver-stomach stagnation-heat syndrome,in terms of BMI,FPG,2h PBG,triglycerides(TG),low-density lipoprotein(LDL-C),fasting insulin(FINs),and fasting C-peptide(CP)Difference(P<0.05);BMI,FPG,TG,LDL-C,FINs,CP in patients with intestinal damp-heat syndrome were significantly higher than those in liver-stomach stagnation-heat syndrome patients;while in 2h PBG,liver-stomach stagnation-heat syndrome patients had higher rates than intestines Patients with damp-heat syndrome.2.The two groups of patients with intestinal damp-heat syndrome and liver-stomach stagnation-heat syndrome had insulin resistance,and the HOMA-IR and HOMA-β of patients with intestinal damp-heat syndrome were higher than those with liver-stomach stagnation-heat syndrome,with statistical differences(P<0.05).3.Multi-class Logistic regression analysis showed that HOMA-IR,HOMA-β,FPG,2h PBG,TG,LDL-C,FINs,C-P,BMI were positively correlated with intestinal damp-heat syndrome.Conclusion:Compared with patients with intestinal damp-heat syndrome of type 2 diabetes,patients with intestinal damp-heat syndrome have more obvious overweight,obesity,disorders of glucose and lipid metabolism and insulin resistance.