Children’s Helicobacter Pylori Infection Affects Whole Blood Zinc,Iron,Calcium,and Copper Changes And The Relationship To Iron Deficiency Anemia

Objective : By studying whether there is any correlation between children’s Helicobacter pylori infection and changes in zinc,iron,calcium,copper in the body,and iron deficiency anemia(IDA),it provides a theoretical basis for future clinical work.Methods:Children aged 5-13 who were in the Pediatric Clinic and inpatients of Yan’an University Hospital from September 2019 to February 2021 were selected for children with gastrointestinal symptoms(including recurrent abdominal pain,nausea and vomiting,loss of appetite,etc.)with poor results of conventional treatment and abdominal abdomen There were 125 children with no obvious abnormalities in B-ultrasound or CT examination,including 68 males and 57 females.All children underwent 13 C urea breath test,and some children underwent histological examination to diagnose Hp infection.There were 28 children with Hp infection.The contents of trace elements zinc(Zn),iron(Fe),calcium(Ca)and copper(Cu)in the two groups of children were determined by electrochemical analysis.The hemoglobin(Hb),mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH)and mean corpuscular hemoglobin concentration(mean corpuscular hemoglobin concentration,MCHC)was used to detect serum iron(SI)by ferroazine colorimetry,and serum ferritin(SF)was detected by electrochemiluminescence immunoassay.SPSS.25 statistical software was used to analyze the changes in the levels of trace elements Zn,Fe,Ca,Cu,Hb,MCV,MCH,MCHC,SI,SF in the two groups of children.Results:1.There is a statistically significant difference in the age of children between the Hp-positive group and the Hp-negative group(P<0.05).There was no statistically significant difference in gender comparison between the two groups of children(P>0.05).2.The content of zinc and iron in the Hp-positive group was lower than that of the Hp-negative group,and the difference was statistically significant(P<0.05);the difference in calcium and copper content between the Hp-positive group and the Hp-negative group was not statistically significant(P>0.05).3.The zinc and iron deficiency rates in the Hp positive group were 71.4% and 32.1%,respectively,and the zinc and iron deficiency rates in the Hp negative group were 29.8%and 10.3%.The difference was statistically significant(P<0.05).There was no significant difference in the rates of calcium and copper deficiency(P>0.05).4.Hb,MCV,MCH,MCHC,SI and SF in the Hp positive group were lower than the Hp negative group,the difference was statistically significant(P<0.05).5.There was a statistically significant difference in the detection rate of iron deficiency anemia between the Hp positive group and the Hp negative group(P<0.05).The detection rate of iron deficiency anemia in children in the Hp positive group was higher than that in the Hp negative group.Conclusion:1.Helicobacter pylori infection is related to age.With age,the positive rate of Helicobacter pylori infection increases;Helicobacter pylori infection has nothing to do with gender.2.Helicobacter pylori infection can lead to deficiencies of zinc and iron in the human body.When children with Helicobacter pylori infection,it is necessary to check trace elements and give corresponding treatment in time to avoid affecting the growth and development of children.3.Helicobacter pylori infection is related to iron deficiency anemia.Helicobacter pylori infection may be the cause of iron deficiency anemia.Clinically,children with unexplained iron deficiency anemia should be tested for Helicobacter pylori.