Analysis Of Clinical Experience Of Professor Hong Minli In The Treatment Of Upper Airway Cough Syndrome Based On The Traditional Chinese Medicine Inheritance Platform

Objective:This study aims to collect the cases of Professor Hong Minli’s treatment of upper airway cough syndrome and use the system of "Traditional Chinese Medicine Inheriting Assistant Platform(V2.5)" to analyze the medication rules of Professor Hong Minli’s treatment of UACS and summarize her clinical experience,so as to provide reference for TCM treatment of this disease.Methods:The outpatients of Professor Hong Minli in the Department of Pulmonary Diseases,Zhangzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine from January 2020 to February 2021,who were consistent with the diagnosis of upper airway cough syndrome were collected.The cases that met the inclusion criteria were collected.The patients’ clinical data were input into the "TCM Inheritance Assistance Platform(V2.5)" system,and the "medical case database" and "prescription database" were established,the database of the patient’s gender,age,symptoms,traditional Chinese medicine(TCM)syndromes and related traditional Chinese medicine,prescriptions were statistically analyzed.At the same time,the prescriptions were analyzed and clustering,so as to find out the potential core combination and form a new prescription.Results:1.A total of 94 cases with 229 consultations were included in this study,including 52 males and 42 females.The proportion of male patients was slightly higher than that of female patients.In the age of onset,30-39 years old age group was in the majority.2.In the analysis of the symptoms of 229 visits,cough was the main symptom.The characteristics of cough included pharyngeal itching cough,throat clearing cough,irritant cough,night cough,paroxysmal cough,seasonal cough,etc,often accompanied by pharyngeal and nasal symptoms.The pharyngeal signs included pharyngeal redness,hyperplasia of pharyngeal follicles,pharyngeal swelling,pharyngeal rosiness,unilateral or bilateral tonsillitis 5 items.The tongue demonstrations were mainly red tongue,light red tongue,the tongue fur were mainly thin white tongue fur,white thick tongue fur,thin yellow tongue fur,and the pulses were mainly string and slippery..3.In this study,the syndrome of pathogenic factors accumulating in Shaoyang was the most common TCM syndrome type,followed by syndrome of phlegm and rheum retention,syndrome of phlegm-heat obstructing the lung,syndrome of damp-heat accumulation,syndrome of wind-cold invasion of the lung,syndrome of spleen-lung qi deficiency,syndrome of liver stagnation and qi stagnation,blood stasis and deficiency of kidney Yin syndrome.4.In this study,a total of 143 traditional Chinese medicines were involved,including Rhizoma Pinelliae,Radix Bupleuri,Fructus Arctii,Poria,Radix Pseudostellariae,Ramulus Cinnamomi,Radix Platycodi,Semen Coicis,Periostracum Cicadae,Cortex Magnoliae of ficinalis and so on.The four qi of medicine are mainly warm,cold and flat,the five flavors are mainly spicy,sweet and bitter,and the main meridians of medicine are lung,spleen and stomach.At the same time,18 groups of drug core combinations were mined through complex system entropy clustering,and 9 groups of potential new prescriptions were extracted from them.Respectively as follows:(1)Radix Paeoniae Alba,Forsythia suspensa,Ramulus Cinnamomi,Radix Pseudostellariae,(2)Caulis Bambusae in taeniam,Fructus Aurantii Immaturus,gardenia,Radix et Rhizoma Rhei,Rhizoma Curcumae Longae,(3)Smen Armeniacae Amarum,Cortex Mori,Trichosanthes Kirilowii,earthworm,(4)Radix Rehmannia,Radix Paeoniae Rubra,radix paeoniae rubra,Semen zizyphi Spinosae,(5)Semen Armeniacae Amarum,ephedra,Gypsum Fibrosum,radix paeoniae rubra,radix trichosanthis,(6)Fructus Arctii,Radix Astragali,Biod Magnolia Bud Radix Scutellariae,Radix Bupleuri,(7)Radix Glycyrrhizae,Belamcanda Sinensis,Talcum Powder,Amomum Kravanh,Caulis Akebiae,(8)Radix Glycyrrhizae,Radix Bupleuri,Radix Pseudostellariae,Amomum Kravanh,Caulis Akebiae(9)Semen Persicae,Flos Carthami,Cortex Eucommiae,Fructus Aurantii,Radix Paeoniae Rubra.Conclusion:1.In the differentiation and treatment of UACS,Dr.Hong believed that the syndrome of pathogenic factors accumulating in Shaoyang was the main syndrome type of the disease,followed by syndrome of phlegm and rheum retention,syndrome of phlegm-heat obstructing the lung,syndrome of damp-heat accumulation,syndrome of wind-cold invasion of the lung and so on.2.The high frequency traditional Chinese medicines used by Dr.Hong in the treatment of UACS mainly include Rhizoma Pinelliae,Radix Bupleuri,Fructus Arctii,Poria,Radix Pseudostellariae,Ramulus Cinnamomi,Radix Platycodi,Semen Coicis,Periostracum Cicadae,Cortex Magnoliae of ficinalis and so on.The four qi of medicine are mainly warm,cold and flat,the five flavors are mainly bitter spicy and sweet,and the main meridians of medicine are lung meridian,spleen meridian and stomach meridian.When the prescription was used,Dr.Hong made good use of classical prescription and composite prescription,the tonification and purgation were combined,the mark and fundamental were taken into account,cold and warm were interused,pungent flavour and bitterness were used together,and the rise and fall were appropriate.Nine new prescriptions were obtained through cluster analysis.3.Professor Hong Minli believed that the disease location of UACS were in the lung,nose and pharynx,and were closely related to the spleen and stomach.The nature of disease of cold,heat,deficiency and solid could be seen each other.The pathogenic factors of disease were mainly phlegm and heat,wind and wet were also not few,Nasopharynx was discordant and lung qi failure to disperse were the basic pathogenesis.Dr.Hong fused the theory of Exogenous Febrile Diseases and Epidemic Febrile Diseases,she mainly treated UACS from four aspects: "Shaoyang,phlegm,dampness-heat and wind".There were also different treatments such as clearing orifices and clearing throat,dredging the liver and relieving depression,promoting blood circulation and removing blood stasis.