Study On The Clinical Experience Of Kang Liangshi In The Treatment Of Non-alcoholic Fatty Liver Disease Based On The Ancient And Modern Medical Cloud Platform System

Objective: This study analyzes and summarizes the medication rules and experience of Kanglao in the treatment of non-alcoholic fatty liver disease by using modern information technology and data mining methods to analyze Medical records of this disease we collected and collated.Methods: This study mainly selected the outpatient medical records of patients with non-alcoholic fatty liver disease who visited Kanglao Clinic from 1995 to 2005.According to the inclusion and exclusion criteria,100 patients were included in the outpatient records,with a total of 389 consultations.After the medical case prescription is calibrated,it is input into the medical case analysis system of the ancient and modern medical case cloud platform for standardized treatment of medical cases.And then frequency statistical method was used to conduct statistics on basic situation,information of four diagnoses,frequency of medication,drug efficacy,etc and association rule method,cluster analysis method and complex network method were used to excavate and analyze drug pairs,drug combinations and core prescriptions.Results: In the medical cases of non-alcoholic fatty liver disease included in this study,the top10 symptoms and signs in frequency were fatigue,flank distension,flank pain,lethargy,poor sleep,dry mouth,abdominal distension,pain,bitter mouth and chest tightness;The top five in the classification of drug efficacy were Xiaoshi,Xingqi,Lishi,Qingre and Huoxue.The 10 most frequently used drugs were Hawthorn,Turmeric Root,Gardenia Root,Licorice,Lotus Leaf,Corn Shake,Cassia Seed,vinegar turtle shell,White Paeonia Lactiflora and Salviae Miltiorrhiza.In the statistics of four qi of drugs,the majority of drugs were mild cold,plain and cold.The five flavors of medicine were mainly sweet,bitter and pungent.The dosage span of core drugs was large;Association rule method was used for analysis,confidence ≥0.46 and support ≥ 0.40 were set,and the repeated combination of front and rear items was eliminated.A total of 14 groups of strongly associated drug combinations were obtained.After analysis,it was concluded that Hawthorn,Curcuma,Gardenia Root and Glycyrhiza were the commonly used drug combinations for Kanglao in the treatment of non-alcoholic fatty liver disease.Clustering analysis was performed on the top 50 traditional Chinese medicines,and the distance type was "absolute distance",and the clustering method was "shortest distance method".All the drugs were divided into nine categories: the first category:hawthorn,turmeric,licorice and gardenia root;The second category: lotus leaf(lotus leaf);the third category: Paeonia lactiflora;the fourth category: corn whiskers;the fifth Category: Tianji Huang;the sixth Category: Salvia miltiorrhiza;the Seventh Category: vinegar turtle armour;The eighth category: Cassiae seed,Cassiae chinensis(Cassiae chinensis);the ninth Category:Dendrobium officinalis;Using complex network analysis,we find the core prescriptions of Kanglao for the treatment of non-alcoholic fatty liver disease were obtained as follows:Hawthorn,Turmeric,Gardenia Root,Licorice,Lotus Leaf,Paeonia lactiflora and Salvia miltiorrhiza.Conclusion: In this study,through the excavation and analysis of the medical cases of Kanglao in the treatment of non-alcoholic fatty liver disease,some experience was obtained.First,Kanglao believed that "stagnation of food,stagnation of qi and dampness-heat" were the basic pathogenesis of non-alcoholic fatty liver disease,and the important ideas of Kanglao in the treatment of non-alcoholic fatty liver disease were to dissipate food and guide stagnation,smooth liver and regulate qi,clear heat and remove dampness,and to invigorate spleen and replenish qi and harmonize qi and blood.Second,Under the framework of the basic pathogenesis,Kanglao used core drugs such as Coke hawthorn,Turmeric,Gardenia Root and Licorice to make up the prescription.For those with hypocholic pain and abdominal pain,he used Yanhusuo and Xuchangqing to promote blood circulation and remove blood stasis.For those with diarrhea,he used phoenix coat and bean shell to regulate qi with broad intestines.Finally,in terms of medication,he mostly selected local medicinal materials with the characteristics of southern Fujian,which were cheap and easy to obtain,to reduce the economic burden of patients,and to explore the prescriptions and theoretical methods for treating liver with both "characteristics of southern Fujian medicine" and "Kang’s characteristics".