| ObjectiveTo observe the safety and clinical effectiveness of Qihuang acupuncture therapy in the treatment of cognitive dysfunction caused by cerebrovascular diseases,and to provide a new way of clinical diagnosis and treatment for cognitive dysfunction caused by cerebrovascular diseases in traditional Chinese medicine.MethodsSixty patients with cognitive impairment caused by cerebrovascular disease in the rehabilitation department,neurology ward and acupuncture outpatient department of Zhongshan Hospital of Traditional Chinese Medicine,who met the inclusion criteria,were randomly assigned to the control group and the treatment group at a ratio of 1:1.Patients in both groups were required to discontinue all medications to improve cognitive function 4 weeks before treatment.Both groups received basic western medicine treatment,including control of blood pressure,blood glucose,blood lipid and antiplatelet aggregation,according to the 2019 Guidelines for the Diagnosis and Treatment of CSVD-Related Cognitive Disorders in China.During the treatment,drugs to improve cognitive function and other drugs that may affect the trial were avoided.The control group was additively given Donepezil tablet 5mg/d on the basis of basic Western medicine treatment for 4 weeks.The treatment group was given Qihuang acupuncture therapy on the basis of basic treatment in the control group:the selected points were as follows:1.,kidney Yin tang shu,after disinfection,take 0.5*1.5 inches to fly QiHuang needle technique quickly penetrated from the point of subcutaneous,into the depth of needle according to patient’s used and acupuncture point location,patients with partial acid bilges feeling,swinging needle handle gently,then exit to subcutaneous needle,row li4 method,after much air gently swinging needle handle out the needles,local dry cotton ball with disinfection on acupuncture in a moment.The above two groups of acupoints were used alternately,one at a time,twice a week,for a total of 4 weeks.Before and after treatment,the following three scales were scored,the main evaluation indicators:MMSE scale;Secondary evaluation measures:MOCA scale and ADL scale,adverse reactions were recorded at any time for safety observation.SPSS 25.0 software was used for statistical analysis of the experimental results,and P<0.05 was taken as the standard of statistical significance to compare the effects of the two groups before and after treatment.Results1、This study included in January 2020 to January 2021 in zhongshan hospital(affiliated hospital of guangzhou university of TCM)rehabilitation of secco admitted into standard small brain vascular disease of the subjects were 68 cases of impaired cognitive function,the test at the end of the treatment group fall off in 1 case(because the patient did not complete the treatment as required by the test),excluding 0 cases,complete 33 cases;In the control group,2 cases fell out(1 case was discontinued due to acute cerebral infarction during treatment,and 1 case voluntarily withdrew from the trial due to its own reasons),0 cases were excluded,and 32 cases completed the treatment,and 65 cases finally completed the treatment.2、In the general data analysis of the acupuncture and medicine group and the western medicine group,the rank sum test was used for age,education level and basic diseases,and the chi-square test was used for gender,smoking history and drinking history,indicating that there was no statistical significance in the general data comparison between the two groups,which could be used for research comparison and analysis.3、MMSE and MMSE are the scales to measure the cognitive function of patients with cognitive dysfunction caused by cerebulovascular disease,and ADL is to measure the ability of daily activities of patients.The intergroup comparison of MMSE,MOCA and ADL scores between the acupuncture and medicine group and the western medicine group before treatment showed no significant difference(P>0.05),indicating that there was no statistical significance in the scores of the three scales before treatment between the two groups,which could be used for research comparison and analysis.4、After four weeks of treatment,the scores of MMSE,MOCA and ADL in the acupuncture and medicine group and the western medicine group were compared with those before treatment,P<0.05,indicating that the two groups of treatment had an effect on improving MMSE,MOCA and ADL scores.5、the needle medicine group and western medicine group,two groups after treatment MMSE,MoCA and ADL scale scores of contrast between groups,P<0.05,statistical contrast differences between the two groups,showed that after treatment the two groups of subjects’ cognitive dysfunction symptoms improved,the treatment group more rise,prompt treatment group curative effect to cerebral small vascular disease cause cognitive dysfunction.6、The two different treatment methods can improve the scores of the three scales.In the evaluation index of the main efficacy indicators(MMSE scale),the total effective rate of the acupuncture and medicine group was 81.80%,and the total effective rate of the western medicine group was 62.50%.The experiment showed that Qihuang acupuncture+western medicine and western medicine alone could improve the cognitive function of patients,but the efficacy of acupuncture and medicine group was better than that of western medicine group.Conclusion1、There is a positive correlation between the daily living ability of patients with CSVD-VCI and their overall cognitive ability,which affects and complements each other.2、From the score values measured in the first three scales of CSVD-VCI patients,it can be seen that the severity of the included CSVD-VCI patients belongs to the category of mild-moderate.Compared with severe CSVD-VCI patients,the compliance is relatively good and the efficacy is obvious.3、In the process of this topic research Gui,patients were more actively cooperate with QiHuang needle therapy,and 33 patients have no treatment,subcutaneous hematoma,pneumothorax,infection and other adverse reactions,the QiHuang small needle therapy for cerebral vascular disease caused by cognitive dysfunction has no obvious side effects,high safety factor,and can effectively improve cerebral small vascular disease to patients with cognitive impairment of cognitive function and daily life ability,curative effect is significant,it has good application prospect and popularization value. |
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