Study On The Relationship Between Senile Leukoaraiosis And Cognitive Dysfunction And TCM Constitution

Objective: To observe and analyze the relationship between senile LA and cognitive impairment,and to study the distribution characteristics of TCM constitution in elderly patients with LA,so as to provide ideas for early diagnosis and early TCM intervention of senile LA cognitive impairment.Methods: One hundred and twenty elderly patients with LA,who were admitted to the Department of Neurology of the second affiliated Hospital of Shandong University of traditional Chinese Medicine from December 1,2019 to January 1,2021,were selected as the observation group.According to MRI-T2 weighted image and ARWMC score system,the observation group was divided into mild and moderate group(n = 62)and severe group(n = 58).The control group was 60 elderly patients with normal head MRI confirmed by physical examination in the second affiliated Hospital of Shandong University of traditional Chinese Medicine in the same period.The executive,attention,memory,language and visual spatial structure functions of all subjects were evaluated,and the relationship between senile LA and cognitive impairment was analyzed.All the subjects completed the TCM Constitution judgment Table according to 9 subscales of constitution classification to study the distribution and characteristics of TCM constitution in elderly patients with LA.Results: 1.Compared with the control group: 1)there were significant differences in long delayed memory,delayed recognition,STT-A time,STTA error number,STT-B time,STT-B error number and SDMT score in mild to moderate groups.2)there were significant differences in immediate memory,short delay memory,long delay memory,delayed recognition,STT-A time,STT-A error number,STT-B time,STT-B error number,SDMT,BNT,CFT and MMSE scores in severe group.2.Compared with the mild to moderate group,there was no significant difference in the score of CFT in the severe group,but there were significant differences in other test scores.3.There are statistical differences in the distribution of peaceful quality,biased quality and biased constitution between the control group and the observation group,in which the biased constitution of the observation group is mainly blood stasis,yang deficiency,phlegm-dampness and qi deficiency.4.There was a statistical difference in the distribution of biased constitution between the mild and moderate group and the severe group,in which the severe group was dominated by blood stasis and phlegmdampness,while the mild to moderate group was dominated by qi deficiency and yang deficiency.Conclusion: 1.There are many areas of cognitive impairment in patients with LA,the main manifestations of mild to moderate patients are executive function,attention,long delayed memory and delayed recognition impairment,language and visual spatial impairment are not obvious,severe patients may have extensive cognitive impairment.2.There is a common physical bias in patients with LA,including blood stasis,yang deficiency,phlegmdampness and qi deficiency,mild to moderate patients with qi deficiency and yang deficiency,severe patients with blood stasis and phlegm-dampness.