Clinical Study On Emotional Disorder Patients With Leukoaraiosis

Objective:To observe the clinical manifestation of emotional disorder patients with leukoaraiosis.Methord:57 LA patients set as patient group and 22 normal control subjects set as control group were tested with MoCA, Hamilton anxiety scale, Hamilton depression scale and self-rating symptom scale.Result:1. Differences in MoCA, Hamilton anxiety scale, Hamilton depression scale and self-rating symptom scale of patient group in comparison with control group were statistically significant (P< 0.05, P< 0.01) after controlling for age, education, and level of depression.2. LA patients was devided into three groups of mild group, moderate group and severe group according to the lesion distribution. The results of those three groups respectively compared with control group were statistically significant (P< 0.05).3. The difference of moderate group in comparsion with control group was statistically significant only in MoCA (P< 0.05). Results of MoCA, self-rating symptom scale and obsessive-compulsive symptoms scores of severe group compared with control group were statistically significant (P< 0.05).4. The MoCA scores and Hamilton anxiety scale,Hamilton depression scale and self-rating symptom scale (anxiety and fear) in three patient groups were statistically significant correlation (P< 0.05).5. Statistically significant correlation appeared between MoCA results and educational background of patients (P< 0.01), between Hamilton depression scale and somatization symptoms significant correlation with age (P< 0.05). However, each test result showed no significant correlation with age and education of control groups (P> 0.05).Conclusion:1. LA patients had clinical manifestations of emotional affective disorder, characterized by significant performance anxiety, depression and obsessive-compulsive symptoms, moreover, some symptoms of mood disorders including terror, paranoid and psychotic symptoms; Mood affective disorders increased with disease aggravated LA.2. Emotional disorder of LA patients was interrelated with decreased cognitive impairment, of which those symptoms of depression, anxiety, terror symptoms highlighted.3. The test results showed that LA patients were more sensitive to self-rating symptom scale than both Hamilton anxiety scale and Hamilton depression scale in emotional disorder test, whereas, those of patients were more sensitive to Hamilton depression scale than self-rating symptom scale according to the results of depression scoring test.