| Objective:1.To observe the clinical effect of Umbilical Inner Ring Acupuncture combined with Zhuang Nationality Medicated thread Moxibustion treat on Primary Dysmenorrhea(PD),compare the curative effect of primary dysmenorrhea treated by oral administration with conventional Western medicine.To provide clinical research data for the promotion and application of Umbilical Inner Ring Acupuncture combined with Zhuang Nationality Medicated thread Moxibustion and the optimization of treatment plan for primary dysmenorrhea.2.To observe the effect of Umbilical Inner Ring Acupuncture combined with Zhuang Nationality Medicated thread Moxibustion on the contents of PGF2αand PGE2 in uterus and β-ep in plasma of rats with primary dysmenorrhea,to study the mechanism of Umbilical Inner Ring Acupuncture combined with Zhuang Nationality Medicated thread Moxibustion treat on primary dysmenorrhea,and to provide reliable experimental data and scientific basis for clinical acupuncture and Moxibustion selection and treatment scheme optimization.Methods:1.60 patients with primary dysmenorrhea were randomly divided into treatment group and control group,30 cases each.The treatment group was treated with Umbilical Inner Ring Acupuncture combined with Zhuang Nationality Medicated thread Moxibustion.The control group was treated with oral ibuprofen sustained-release capsule.After 3 consecutive menstrual cycles,the scores of dysmenorrhea symptoms and VAS were compared before and after treatment to determine the clinical efficacy.2.40 female SD rats were randomly divided into four groups: blank group,model group,western medicine group and zhuangyi group,10 rats in each group.Except the blank group,the other three groups used estradiol benzoate and oxytocin to construct the primary dysmenorrhea rat model for 10 days.From the first day after the model was made,the western medicine group was given ibuprofen orally once a day for 10 days,and zhuangyi group was treated with Umbilical Inner Ring Acupuncture combined with Zhuang Nationality Medicated thread Moxibustion once a day for 10 consecutive days.After 10 days of continuous treatment,all rats in the four groups were intraperitoneally injected with oxytocin to observe the times of body torsion and the latent time of the first body torsion,and t he contents of PGF2 α,PGE2 in uterus and β-Ep in plasma were measured by ELISA.Results:1.(1)The scores of dysmenorrhea symptoms of the two groups were significantly lower than before treatment(p < 0.05),and compared with the control group,the scores of dysmenorrhea symptoms in the treatment group were significantly lower(p < 0.05),the difference was statistically significant.(2)The VAS scores of the two groups were significantly lower than than before treatment,(p < 0.05),and compared with the control group,the VAS scores of the treatment group were significantly lower(p < 0.05),the difference was statistically significant.(3)After 3 menstrual cycles of treatment,the total effective rate of the treatment group was 100%.Compared with the control group,there was no significant difference(P > 0.05).2.(1)Compared with the blank group,the number of sprains in the model group was significantly increased(p < 0.05),and the number of sprains in both the western medicine group and the zhuangyi group was significantly decreased,and the number of sprains in the zhuangyi group was significantly decreased compared with the western medicine group,the difference was statistically significant(p < 0.05).(2)Compared with the model group,the latency of the first torsion was significantly longer in the zhuangyi group and the western medicine group(p< 0.05).The latency of first torsion in zhuangyi group was significantly longer than that in western medicine group(p < 0.05).the difference was statistically significant.(3)Compared with blank group,the level of PGE2 in uterus of model group was significantly lower(p < 0.05).Compared with the model group,the level of PGE2 in uterus tissue of the zhuangyi group and the western medicine group was increased significantly(p < 0.05),the level of PGE2 in zhuangyi group was higher than the western medicine group,the difference was statistically significant(p < 0.05).and there was significant difference(p < 0.05).(4)Compared with the control group,the level of PGF2α in the uterus of model group was significantly higher(P < 0.05).Compared with the model group,the level of PGF2α in uterus tissue in the western medicine group and zhuangyi group decreased significantly(p < 0.05),the level of PGF2α in zhuangyi group was lower than the western medicine group,the difference was statistically significant(p < 0.05).(5)Compared with blank group,the level of plasma β-EP in model group was significantly lower(p < 0.05).Compared with the model group,the level of plasma β-EP in the Western medicine group and zhuangyi group was higher(p< 0.05),and the level of β-EP in zhuangyi group was higher than that in the western medicine group(p < 0.05).the difference was statistically significant(p < 0.05).Conclusions:1.The Umbilical Inner Ring Acupuncture combined with Zhuang Nationality Medicated thread Moxibustion can significantly reduce the severity of abdominal pain and relieve dysmenorrhea symptoms in patients with primary dysmenorrhea.Its clinical efficiency is comparable to that of oral ibuprofen.2.The Umbilical Inner Ring Acupuncture combined with Zhuang Nationality Medicated thread Moxibustion can significantly decrease the level of PGF2αand increase the level of PGE2 in uterus of primary dysmenorrhea model rats,alleviate the contraction of uterus and reduce the pain.3.The Umbilical Inner Ring Acupuncture combined with Zhuang Nationality Medicated thread Moxibustion can effectively increase the content of β-EP in the blood of primary dysmenorrhea model rats and exert analgesic effect to achieve therapeutic effect. |
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