Clinical Study Of Modified Sangma Dihuang Granule In Treatment Of Mild To Moderate Vascular Dementia Of Spleen And Kidney Deficiency Type

Objective: The purpose of this study is to observe the clinical efficacy of modified Sangma Dihuang Granule in treating patients with mild to moderate vascular dementia of spleen and kidney deficiency type,explore the etiology and pathogenesis of this disease,analyze the mechanism of action of modified Sangma Dihuang Granule and evaluate its safety,so as to explore new methods and new ideas for treating vascular dementia with traditional Chinese medicine.Methods: In this study,a total of 66 patients who met the inclusion criteria were selected and treated in the Department of Encephalopathy of Weifang Traditional Chinese Medicine Hospital from September 2019 to September 2020.They were randomly divided into treatment group(33 cases)and control group(33 cases).Patients in the control group were given oral Aricept and combined with conventional western medicine treatment for cerebrovascular diseases.On the basis of the control group,the treatment group was given modified Sangma Dihuang Granule orally for 3 consecutive courses of treatment for 3 months.Before and after treatment,the Mini-mental State Examination(MMSE)score,TCM syndrome scale score,Modified Barthel Index Scale(MBI)score,Blessed Behavior Scale(BBS)total score and individual scores were evaluated.The total effective rate was calculated and the clinical efficacy was analyzed.The safety indexes were observed and the adverse reactions were recorded.In this study,SPSS22.0 statistical software was used to analyze and process the data.Results: During the study,the number of patients who fell off was 3 in the treatment group and 3 in the control group,and 30 patients in the treatment group and 30 patients in the control group were finally completed.In terms of total effective rate,the curative effect of TCM syndrome in treatment group and control group was 93.33%,73.33%,and the recovery effect of cognitive function was 86.67%,73.33%,respectively.The total effective rate in treatment group was better than that in control group(P<0.05).After treatment,TCM syndrome score,MMSE score,MBI score,BBS total score and individual scores of the two groups were significantly improved compared with those before treatment(P<0.01).In TCM syndrome score,MMSE score,BBS total score and individual scores of personality behavior and living ability,the treatment group was obviously superior to the control group(P<0.01).In terms of MBI score and daily habit score in BBS,there was no statistical difference between the two groups(P>0.05),and the curative effect of the two groups was equal.There was no statistical difference in security index(P>0.05).Conclusion: Modified Sangma Dihuang Granule is effective in treating patients with mild to moderate vascular dementia of spleen and kidney deficiency type.It is superior to western medicine alone in improving TCM syndrome,promoting recovery of cognitive function,changing personality behavior and living ability,and has the same effect as western medicine alone in improving daily life ability and daily habits of patients,without obvious toxic and side effects,which is worthy of further study and promotion.