| Objective:To explore the correlation between platelet count(PLT),mean platelet volume(MPV),the systemic immune infammation index(SII)and fibrinogen(FIB)in preoperative blood before surgery and the clinical pathological features of cervical cancer.To provide laboratory basis for evaluation or prediction of cervical cancer.Methods:A total of 209 patients with cervical cancer treated in the Hospital of Yan Bian University from January 2010 to November 2020(cervical cancer group),at the same time,149 healthy women(health group)were selected as control group for retrospective analysis.Record the basic information including age,recorded,including age,nationality,past history and blood routine tests were collected for the first time before treatment.And recorded The neutrophil count,lymphocyte count,PLT,MPV,FIB,and SII(SII=platelet*neutrophil-to-lymphocyte ratio).Using the receiver operating characteristic(AUC)to determine the area under curve of the PLT,MPV,SII and FIB,analysised whether there is any difference between cervical cancer group and health groups about the index of inflammation.Compared the difference of the index between each group and get the value of the relevant parameters in the diagnosis of cervical cancer and the clinical pathological features of cervical cancer.Results:1.Compared with healthy group,the PLT,MPV,SII and FIB of cervical cancer group had statistically significant(P<0.001).2.In cervical cancer group,the PLT,SII and FIB had statistically significant in differentiation degree(P<0.05).PLT,MPV,SII and FIB had statistically significant in tumor size.PLT,MPV,SII and FIB had no statistically significant in lymph node metastasis in cervical cancer group(P>0.05).3.The PLT,MPV had statistically significant in cervical squamous cell carcinoma and cervical adenocarcinoma(P<0.05).But the SII and FIB had no statistically significant in cervical squamous cell carcinoma and cervical adenocarcinoma(P>0.05).4.The curve analysis of the diagnosis of cervical cancer showed that:The AUC of PLT was 0.607,95%confidence level(CI):0.547-0.667,PLT cut off at 240,the sensitivity was 58.85%,the specificity was 61.07%;The AUC of MPV was 0.627,95%CI:0.570-0.685,MPV cut off at 10.2,the sensitivity was 46.41%,the specificity was 75.84%;The AUC of SII was 0.617,95%CI:0.560-0.675,SII cut off at 534.74,the sensitivity was 43.54 degrees,the specificity was 82.55%;The AUC of FIB was 0.698,95%CI:0.645-0.752,FIB cut off at 3.43,the sensitivity was 47.37%,the specificity was 88.59%;The AUC of the PLT+MPV+SII was 0.750,95%CI:0.700-0.800,the sensitivity was 70.81%,the specificity was 66.44%;The AUC of the PLT+MPV+SII+FIB was 0.797,95%CI:0.752-0.840,the sensitivity was 67.46,the specificity was 76.51%.Conclusion:1.Before treatment the PLT,MPV,SII,FIB can be used as a reference index for evaluation or prediction of cervical cancer.PLT,MPV,SII combined with FIB or not can improve the diagnostic rate of cervical cancer.They are easy to detect,convenient and cheap,and have good repeatability.2.The value of PLT,SII,FIB can be used to evaluate the differentiation of cervical cancer.PLT,MPV,SII,FIB can be used to assess the mass size of cervical cancer.3.PLT,MPV can be a predictor of cervical squamous cell carcinoma and adenocarcinoma. |
