| Objective:The aim of this study was to observe the changes of serum Elabela level in patients with acute myocardial infarction and the control group,and to analyze the correlation between Elabela level and various clinical indicators and Gensini score.Methods: A total of 112 patients with acute ST-segment elevation myocardial infarction within 12 hours of onset were enrolled in the coronary heart disease ward of the Second Affiliated Hospital of Dalian Medical University from June 2020 to December 2020,and 51 patients with negative coronary angiography during the same period were selected as the control group.All patients with acute myocardial infarction received emergency coronary angiography and percutaneous coronary intervention in our hospital,and standardized treatment was given after surgery.According to whether or not there was heart failure after acute myocardial infarction,54 patients were divided into Killip grade I group and 58 patients were classified into Killip grade IⅠ-Ⅳ group.General clinical data were collected,including age,sex,blood pressure,heart rate,history of hypertension,history of diabetes,smoking history and electrocardiogram after admission.The peripheral venous blood of patients with acute myocardial infarction within 24 hours of onset was collected to detect the levels of routine blood,myocardial markers,NT-pro BNP,fasting blood glucose,Hb A1 c,total cholesterol,triglyceride,high density lipoprotein,low density lipoprotein,transaminase,urea nitrogen,serum creatinine,uric acid and so on.Serum Elabela levels in all patients with acute myocardial infarction were quantitatively measured by enzym-linked immunosorbent assay(ELISA)within 24 hours after the onset of chest pain and before discharge after treatment(5-7 days).According to the results of coronary angiography,the degree of coronary artery stenosis was evaluated by Gensini score.All data were analyzed using SPSS 26.0 statistical software.Results: 1.The serum Elabela level of patients with acute myocardial infarction within24 hours after onset was significantly higher than that of the control group.The Killip grade I group was significantly higher than the control group(4.94±2.48 ng/m L vs2.65±0.57 ng/m L,P<0.01),and the difference was statistically significant.The level of Elabela in the Killip ⅠⅠ-Ⅳ group was significantly higher than that in the Killip Ⅰ group(11.83±2.67 ng/m L vs 4.94±2.48 ng/m L,P<0.01),and the difference was statistically significant.2.Acute myocardial infarction in the Killip Ⅰ group was slightly decreased before discharge(4.45±1.83ng/m Lvs 4.94±2.48ng/m L,P BBB 0 0.05)compared with24 h after onset,and the difference was not statistically significant.Serum Elabela concentration in the Killip ⅠⅠ-Ⅳ group was slightly lower before discharge than within24 h after onset(10.85±3.51ng/m L vs 11.83±2.67ng/m L,P > 0.05),and the difference was not statistically significant.3.There was a positive correlation between serum Elabela level and coronary Gensini score within 24 hours after the onset of acute myocardial infarction(r=0.410,P<0.01).4.Within 24 hours after the onset of acute myocardial infarction group,serum Elabela level was positively correlated with NT-pro BNP(r=0.470,P<0.01),and negatively correlated with LVEF(r=-0.486,P<0.01),and had no significant correlation with c Tn I,WBC,PLT,ALT,AST,BUN,Cr,UA,TC,TG,HDL-C,LDL-C,Apo A,Apo B,systolic and diastolic blood pressure.Conclusion: 1.Serum Elabela levels in patients with acute myocardial infarction were significantly higher than those in healthy controls,suggesting that Elabela may play a role in the occurrence and development of acute myocardial infarction.2.The serum Elabela level of patients with acute myocardial infarction within 24 hours after the onset of chest pain in the Killip ⅠⅠ～Ⅳ group was more significantly higher than that in the Killip Ⅰ group,which was positively correlated with NT-pro BNP and negatively correlated with LVEF.After treatment,the serum Elabela level before discharge was slightly lower than that within 24 hours after the onset of chest pain,but there was no statistical significance.These results suggest that ELABELA may be related to cardiac function and ventricular remodeling after myocardial infarction.3.Serum Elabela level within 24 hours after the onset of chest pain in patients with acute myocardial infarction was positively correlated with Gensini score,suggesting that ELABELA may reflect the severity of coronary artery lesions. |
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