| Objective: Coronary heart disease(CHD)is a multifactorial disease that is influenced by lifestyle,environmental factors,and genetic factors.Although considerable progress in therapeutic strategies,the global incidence and mortality of CHD remain high in the past several decades.ELA has been confirmed to be involved in the progress of coronary atherosclerosis,whereas the role of ELA in human coronary atherosclerosis has not been investigated.We aimed to characterize the plasma ELA levels of CHD patients and to explore its relationship with the severity of coronary artery stenosis and other clinical data.We hope to provide a new method for the diagnosis and assessment of CHD and a new target for the treatment of CHD.Methods: A total of 500 patients who underwent coronary angiography in the Cardiology Department of Qingdao Municipal Hospital from January 2018 to December 2018 were collected.A total of 120 subjects were selected from 500 patients,which were diveded into three groups,including AMI group,SAP group and control group.There were no significant differences in age,gender,BMI,history of hypertension,history of diabetes,and history of smoking among three groups.Basic information and clinical data of patients in each group were collected.The concentrations of ELA in plasma were measured by enzyme-linked immunosorbent assay(ELISA).The Gensini score was calculated according to the results of coronary angiography(CAG).LVEF was measured by biplane Simpson's method.Blood glucose,blood lipid and other biochemical indicators were measured by biochemical analyzer.The statistical analyses were carried out with SPSS 22.0.Univariate analysis of variance was conducted to compare differences in plasma ELA level and other clinical data among the three groups.The correlation between the plasma ELA levels of CHD patients with the severity of coronary artery stenosis and other clinical indicators was explored by Pearson correlation analysis.The receiver operating characteristic curve(ROC curve)was conducted to evaluate the diagnostic value of plasma ELA and calculate its optimal cutoff value.Results: 1.There were no significant differences in age,gender,BMI,SBP,DBP,FBG,TG,TC,HDL,LDL,serum creatinine(Scr),smoking history,hypertension history anddiabetes history among three groups(P>0.05).Compared with control group or SAP group,AMI group had significantly lower levels of blood urea nitrogen(BUN)and LVEF,and significantly higher levels of white blood cell(WBC),Gensini score and BNP(P<0.05).Compared with control group,Gensini score was significantly higher in SAP group(P<0.05).2.The plasma ELA level in AMI group was significantly higher than that in control group and SAP group(P<0.05).The plasma ELA level of SAP group was higher than that in control group,while the difference was not statistically significant(P>0.05).3.Plasma ELA levels of patients with CHD were positively correlated with the levels of Gensini score(r=0.559,P<0.01)and BNP(r=0.395,P<0.01),and negatively correlated with the levels of LVEF(r=-0.440,P<0.01)and DBP(r=-0.469,P<0.01).There was no statistically significant correlation between ELA and other variables(P>0.05).Regression analysis showed ELA is correlated with CHD.4.The area under curve of ELA was 0.732(95% CI: 0.643-0.809,P<0.01),the sensitivity was 53.75%,the specificity was 85.0%,and optimal cutoff value was 2.73 ng/ml.Conclusion: The present study demonstrates for the first time that plasma ELA levels were increased in patients with CHD.Compared with healthy controls,SAP patients had only a tendency to increase ELA but no statistical significance.The plasma ELA levels were positively correlated with the severity of coronary artery stenosis and negatively correlated with cardiac function and DBP in patients with CHD.ELA may be involved in the development of CHD,and have a predictive effect on the severity of CHD. |
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