Correlation Between TCM Syndrome Types And Salt Intake And Arterial Elasticity In Hypertensive Patients

Objective:Hypertension is a complex chronic disease caused by many factors,which causes different degrees of damage to target organs.Modern medical research shows that sodium salt is closely related to the occurrence and development of hypertension and has a "U" curve relationship,which will accelerate the injury process of target organs such as heart,brain,kidney and blood vessels.Traditional medicine treats hypertension by syndrome differentiation and classification,and the intake of sodium salt and the degree of vascular injury are different among different syndromes.The purpose of this study is to study the difference of salt intake among different TCM syndromes of hypertensive patients and its correlation with the indexes reflecting arterial elasticity including brachial-ankle pulse wave velocity,pulse pressure index and dynamic arteriosclerosis index,and to discuss the possible pathogenesis,so as to provide reference and basis for clinical treatment of hypertension by TCM syndrome differentiation combined with Western medicine and delay arteriosclerosis.Method:A total of 154 patients with essential hypertension who met the inclusion criteria from December 2019 to December 2020 were included in the outpatient and inpatient departments of Yan ’an Hospital of Kunming for TCM syndrome differentiation,which was divided into phlegm-dampness syndrome(n=42),liver-yang hyperactivity syndrome(n=37),yin deficiency and yang hyperactivity syndrome(n=38)and yin and yang deficiency syndrome(n=37)After collecting and sorting out the data,statistical processing was carried out to analyze the difference of salt intake among different TCM syndrome types and the correlation between salt intake and arterial elasticity.Results:1.sex,age,Body mass index(BMI),dietary score,estimated salt intake,24 h urine sodium,24 h urine potassium,blood sodium,blood potassium,total cholesterol(TC),high density lipoprotein(HDL-c),HDL-C),low density lipoprotein(LDL-C),creatinine level,estimated glomerular filtration rate(e GFR)level,Plasma renin activity,PRA)was significantly different among TCM syndromes(P<0.05),while triglyceride(TG)and aldosterone(ALD)were not significantly different among TCM syndromes(P > 0.05).Comparing the TCM syndrome types,the food score and estimated salt intake are the highest in phlegm-dampness syndrome,and the lowest in yin-yang deficiency syndrome(P<0.05).Bapwv value is highest in deficiency of both yin and yang syndrome,and lowest in excess of phlegm-dampness syndrome(p<0.05).2.The age is 20 years old.Patients aged 20-40 have the highest salt intake,while those aged over 60 have the lowest salt intake(P<0.05).Male(10.256 5.94)g is higher than female(7.614 4.18)g(P<0.05).Pearson correlation analysis showed that salt intake was positively correlated with diet score,24-hour urine potassium,urine sodium/urine potassium(P<0.05),and negatively correlated with age and ALD(P<0.05),among which salt intake was highly correlated with diet score.Ba PWV was positively correlated with age,SBP,PPI and AASI(P<0.05),and negatively correlated with BMI and 24-hour urinary potassium(P<0.05),among which ba PWV was highly correlated with age.AASI was positively correlated with gender,age,Systolic blood pressure(SBP),blood sodium,TC,PPI and ba PWV(p<0.05),but negatively correlated with diastolic blood pressure(DBP)and 24-hour urine potassium(p<0.05),among which AASI was highly correlated with PPI.PPI was positively correlated with gender,age,AASI,ba PWV(P<0.05),and negatively correlated with DBP,24 h urine potassium,creatinine and PRA(P<0.05),among which PPI was highly correlated with DBP and AASI.Multiple regression analysis:age,SBP and PPI are the factors affecting ba PWV;Age and blood sodium are the factors affecting AASI.DBP,24 h urine potassium,AASI and ba PWV are the factors affecting PPI.Conclusion:(1).The estimated salt intake of hypertensive patients with the syndrome of phlegm-dampness in the TCM syndrome is the highest,and the salt intake of male patients is greater than that of female patients.(2).The ba PWV of Yin and Yang deficiency syndrome in TCM of hypertensive patients is the highest,indicating that the arterial stiffness of hypertensive patients with Yin and Yang deficiency syndrome is the highest.(3)Age and blood sodium are factors that affect AASI;age,SBP,and PPI are factors that affect bapwv;DBP,24 h urine potassium,AASI,and bapwv are factors that affect PPI.(4)ba pwv,PPI,AASI can predict the elasticity of arteries,which increases with age,there is a significant positive correlation among them.