| ObjectiveTo investigate the associa tion between serum resistin concentration andthe change of large arteria l elasticity in patients with essentia l hypertension.Methods271 recruited subjects were divided into the control group and thehypertension group. Blood pressure,height,body weight,waist circumference,hip,body mass index (BMI) were measured. Serum resistin concentration wasassessed by enzyme immunoassay, fasting serum insulin and TNF-αwere measuredusing radioimmunity kits. Insulin resista nce was evaluated by insulin resista nce index(HOMA-IR).Brachia l ankle pulse wave velocity (baPWV) was tested by the fullautomatic arteriosclerosis dia gnostic instrument.Results(1) The serum resistin concentration ,baPWV and TNF-αwas increased inhypertension group compared to the control group［(0.65±0.04) ng/mL vs (0.59±0.06)ng/mL;(1513.24±182.30) cm/s vs (1301.69±151.15) cm/s;(5.69±1.98) ng/ mL vs(3.83±2.38) ng/mL；P<0.01 respectively］.(2) Pearson correla tion analysis showed thatresistin was positively correla ted with baPWV,TNF-α. and HOMA-IR in thehypertension group(r=0.219,r =0.212, r=0.183, P<0.05 respectively);partia lcorrela tion analysis revea led that resistin was positively correla ted with baPWV andTNF-α(r=0.238,P<0.01；r=0.207,P<0.05), but not correla ted with HOMA-IR in thehypertension group. (3) Multivariate regression analysis showed that SBP, age, bloodTNF-αand resistin level were risk factors of arteria l elasticity in the hypertensiongroup . ConclusiConclusionThe serum resistin concentration was increased in hypertension group,which was that resistin was positively correla ted with baPWV. Meanwhile, age andSBP was still the ma inly risk factors of arteria l elasticity. Background Patients with essential hypertension are usually accompanied by endothelial dysfunction and inflammatory reaction. Previous experimental and clinical studies have proved that thrombomodulin (TM) and tumor necrosis factor-a (TNF-a) were increased in patients with essential hypertension. Whereas, there was a paucity of information on the relationship between TM, TNF-a concentration and the largearterial stiffness in hypertensive patients.Objective To investigate the association between thrombomodulin , tumor necrosis factor-a concentration and the large arterial stiffness in patients with essential hypertension.Methods 303 recruited subjects were divided into the control group (n=137) and the hypertension (n=166). Blood pressure , height, body weight, waist circumference,hip,body mass index (BMI) were measured. Brachial ankle pulse wave velocity (baPWV) was tested by the full-automatic arteriosclerosis diagnostic instrument. Plasma thrombomodulin concentration was assessed by enzyme immunoassay, fasting serum TNF-a were measured using radioimmunity kits.Results (1) The baPWV and TM, TNF-a concentration were significantly increase dinhypertension group compared to the control group [baPWV: (1539.72±233.42) vs(1302.99±149.37) cm/s ,P<0.01 ; TM: (12.50+=3.76) vs (10.49±2.76) ug/L,P<0.01 ; TNF-a: (5.26±1.25) vs (4.08±0.84) ug/L,P <0.01]. (2) Pearson relationanalysis showed that the TM level was significantly and positively correlated with age (r=0.335) , SBP (r=0.280) , PP (r=0.284) ,TNF-a (r =0.307) and baPWV (r =0.473) in the hypertension group(P all<0.01); TNF-αwas positively correla ted with age(r=0.288), SBP (r =0.299), DBP (r=0.164), PP (r=0.212), TM (r =0.307) andbaPWV (r =0.512)(P all<0.05). (3) Multivariate regression analysis showed thatSBP, age, TM and TNF-αwere risk factors of large arteria l stiffness in thehypertension group (R2 =0.562,P<0.01).ConclusionConclusionsThe TM and TNF-αconcentration was significa ntly increased inhypertensive patients, both of them were possibly releva nt to the development ofatherosclerosis in patients with essentia l hypertension. |
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