| Objective: This study focused on two theories of femoral head necrosis,namely abnormal lipid metabolism and hypercoagulable state of blood,and was set up as a group study by randomized number table method to observe the effects of Yi-Qi Bone Renewal Compound on blood rheology and lipid levels in patients with early femoral head necrosis,and to explore the unique advantages of Chinese medicine in early femoral head necrosis,with a view to better improving clinical treatment methods and reducing or delaying the risk of femoral head collapse in patients.Methods:The cases were obtained from 44 patients with femoral head necrosis who met the inclusion criteria and were treated at the Third Affiliated Hospital of Yunnan University of Traditional Chinese Medicine from December 2019 to January 2021,including 28 males and 16 females,with a minimum age of 44 years and a maximum age of 73 years;a total of 40 cases of non-traumatic femoral head necrosis were actually collected due to incomplete treatment courses and non-cooperation with efficacy evaluation during the study A total of 40 patients with non-traumatic femoral head necrosis(ARCO stage I and II)were collected for the study;the 40 eligible patients were divided into observation and control groups using the random number table method,with 20 cases in the observation group and 20 cases in the control group.Both the control group and the observation group were given the basic treatment of aspirin enteric dissolved tablets orally(Bayer Healthcare Co.,Ltd.,State Drug Quantifier J20171021)),while the control group was given the basic treatment of Tao Hong Si Wu Tang orally,and the observation group was given the basic treatment of Yi Qi Xuan Bone Combination(In-Hospital Preparation of the Third Affiliated Hospital of Yunnan University of Traditional Chinese Medicine,Injury No.4: Yunnan Pharmaceutical Preparation No.(Z)20082314A);and Laboratory serological assessment,VAS score assessment and Harris score assessment were performed 1 day before and 1 week,2 weeks and 4 weeks after taking the medication respectively,and finally a database was established and SPSS 25.0 was applied for statistical analysis.Results.1.Baseline comparison.There were no statistically significant differences between the two groups in terms of gender,age,site of injury,comparison of pre-treatment haematological and lipid indices,VAS pain score and Harris score results(P>0.05),and the baseline level conditions were the same in both groups and were comparable.2.Intra-group and inter-group comparisons of blood rheology indexes and lipid indexes Intra-group comparison.There was no statistically significant difference between the two groups after 1week of treatment compared to before treatment in terms of haematological and lipid indices(P>0.05).The rheological parameters(200/s,60/s,10/s,PV,HCT)decreased in both groups after 2 weeks of treatment(P < 0.05);the values of lipid parameters(TC,TG,LDL)decreased in both groups(P < 0.05);the value of HDL increased(P < 0.05).In the observation group,after 4 weeks of treatment,the rheological parameters(200/s,60/s,10/s,PV,HCT)decreased(P < 0.01);the values of lipid parameters(TC,TG,LDL)decreased(P < 0.01);the values of HDL increased(P < 0.01);in the control group,after 4 weeks of treatment,the rheological parameters(200/s,60/s,10/s,PV,HCT)decreased(P < 0.01).In the control group,after 4 weeks of treatment,there was a decrease in the rheological parameters(200/s,60/s,10/s,PV,HCT)(P < 0.05);a decrease in the lipid parameters(TC,TG,LDL)(P < 0.05);and an increase in the HDL values(P < 0.05).This indicates that both groups were able to reduce the rheological and lipid indexes in patients with ONFH after 2 and 4 weeks of treatment.Comparison between groups.There was no statistical significance between the observation group and the control group in the indicators after 1 and 2 weeks of treatment(P > 0.05);the observation group was better than the control group in reducing the rheological indicators(200/s,60/s,10/s,PV,HCT),lipid indicators(TC,TG,LDL)and increasing the HDL values after 4 weeks of treatment(P < 0.05);indicating that the observation group was better than the control group in reducing the The observation group was better than the control group in reducing blood rheology indexes and TC,TG and LDL;the observation group was better than the control group in improving HDL indexes.3.Comparison of VAS pain scores.Intra-group comparison: There was no statistically significant difference between the two groups of patients after 1 week of treatment compared to before treatment(P>0.05);the difference in VAS pain scores between the two groups of patients after 2weeks and 4 weeks of treatment compared to before treatment was statistically significant(P<0.01),indicating that there was a significant reduction in VAS pain scores between the two groups of patients after 2 weeks and 4 weeks of treatment.The difference between the two groups was not statistically significant(P>0.05)when comparing the VAS scores after 1 week and 2 weeks of treatment;the difference was statistically significant(P<0.05)when comparing the two groups after 4 weeks of treatment,indicating that the VAS pain score of the observation group was better than that of the control group after 4 weeks of treatment,and the observation group was better than the control group in terms of pain relief of the affected limbs.4.Comparison of Harris scores Intra-group comparison.There was no statistically significant difference between the Harris scores of the hip joint in the observation group after 1 week of treatment and before treatment(P>0.05);the difference between the Harris scores of the hip joint in the observation group after 2 weeks of treatment and before treatment was statistically significant in terms of pain,function and total score(P<0.01),in terms of mobility(P<0.05)and in terms of deformity(P<0.05).In the observation group,after 4 weeks of treatment,compared with the pre-treatment period,the difference in hip Harris score was statistically significant in terms of pain,function and total score(P < 0.01);statistically significant in terms of deformity(P < 0.05),but not in terms of mobility(P > 0.05).In the control group,there was no statistically significant difference between the Harris scores of the hip joint after 1 week of treatment and before treatment(P>0.05);in the control group,there was a statistically significant difference between the Harris scores of the hip joint after 2 weeks of treatment and before treatment in terms of pain and total score(P<0.01);in terms of function(P<0.05),and in terms of deformity and mobility(P>0.05).There was no statistically significant difference(P > 0.05).In the control group,after 4 weeks of treatment,compared with the pre-treatment period,the difference in hip Harris score was statistically significant in terms of pain and total score(P < 0.01);statistically significant in terms of function(P < 0.05),but not in terms of deformity and mobility(P > 0.05).Comparison between groups.(1)There was no statistically significant difference between the two groups in all Harris scores after 1 week of treatment(P > 0.05).(2)When comparing the Harris scores between the observation group and the control group after 2 weeks of treatment,the differences were statistically significant in terms of pain and total score(P < 0.05),but not in terms of function,mobility and deformity(P > 0.05).(3)When comparing the Harris score of the control group after 4 weeks of treatment,the difference was statistically significant in terms of pain,function and total score(P<0.05),but not in terms of mobility and deformity(P>0.05).Conclusion: Yi Qi Ren Ren Ren Bone Combination can reduce blood viscosity and blood lipid indexes in patients with early stage femoral head necrosis,especially in patients who took it for a long time after treatment,the indexes decreased particularly significantly,indirectly indicating that Yi Qi Ren Bone Combination can improve patients’ blood hypercoagulability,which in turn improves patients’ blood flow,accelerates venous blood flow,reopens diseased blood vessels,unblocks the nutritional vessels of the femoral head,and promotes the removal of metabolic products to clear bad bone mass for new bone formation,delaying the risk of femoral head collapse and improving patients’ hip joint symptoms. |
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