Correlational Analysis Between The Levels Of Macrophages And Neutrophils In Peripheral Blood With Femoral Head Necrosis

Background:Femoral head necrosis is a common or frequently-occurring orthopedic disease in which the osteoarthritis of the hip joint collapses,deforms,necrosis,and finally the hip osteoarthritis occurs,causing the patient to lose joint function.There are many studies on the etiology of femoral head necrosis.The current mainstream theories include blood stagnation theory,lipid metabolism abnormality theory,bone cell apoptosis theory,osteoporosis theory and so on.Even immunological factors play a role in it.The common feature is that blood flow in the femoral head is blocked for various reasons including mechanical and non-mechanical,and bone ischemia leads to bone necrosis.However,its specific pathogenic mechanism has not been able to elaborate so far.Most previous studies focused on abnormal blood lipid metabolism,fat embolism,etc.,and related experimental studies have also shown that abnormal lipid metabolism is associated with femoral head necrosis.Peripheral blood cells are an important part of the body's homeostasis regulation and bone metabolism.However,the correlation between the levels of macrophages and neutrophils in the peripheral blood cells and the necrosis of the femoral head is rarely studied and reported.This article explores the correlation between peripheral blood macrophages and neutrophil levels and femoral head necrosis(ONFH)from retrospective cases.Methods:A total of 984 cases of ONFH and femoral neck fractures(non-ONFH)diagnosed at the Department of Orthopedics at our institution between January 1,2011 and December 31,2016 were retrospectively reviewed.The ONFH and non-ONFH groups comprised 488 and 496 cases,respectively.Basic information and peripheral blood cell levels of the two groups were compared.Results:The patients' mean age was 59.89 ± 17.06 years(range: 38–82 years).There were 457 male and 527 female patients,with a male-to-female ratio of 1:1.15.We found that neutrophil granulocyte levels and percentage of neutrophil granulocytes were significantly different between the ONFH and non-ONFH groups.Multimodal regression analysis showed that the percentage of neutrophil granulocytes was an independent protective factor against ONFH.Conclusions:Mononuclear macrophages and neutrophil percentages have a certain degree of correlation with femoral head necrosis.This provides new ideas and directions for early diagnosis and early intervention in the treatment of femoral head necrosis and delaying the process of femoral head necrosis.