Analysis And Study On The Expression Level Of Serum S100B Protein In Children With Convulsion

Objective:to study the clinical significance of serum S100 B protein expression after convulsion in children and its relationship with brain injury in children with convulsion.Methods:From November 2019 to November 2020,children with convulsions who were hospitalized in the Department of Neurology of Changchun Children’s Hospital from November 2019 to November 2020 and met the inclusion criteria were selected as the observation group.According to the causes of the attack,they were divided into febrile convulsion group(n = 157),epilepsy group(n = 83),viral encephalitis group(n = 23),suppurative encephalitis group(n = 10)and unexplained convulsion group(n = 37).At the same time,30 children with acute upper respiratory tract infection hospitalized in the same period were selected as the control group.S100 B protein was detected by double antibody sandwich method and immunochromatography,and the relationship between serum S100 B protein expression and brain injury in children with convulsion was analyzed.Results:1.Compared with the control group,the concentration of serum S100 B protein in the observation group was significantly higher than that in the control group(p < 0.05);2.In febrile convulsion group,the concentration of serum S100 B protein in complex febrile convulsion group was significantly higher than that in simple febrile convulsion group(p < 0.05);3.there was no significant difference in serum S100 B protein expression among febrile convulsion group,epilepsy group,viral encephalitis group,suppurative encephalitis group and unexplained convulsion group(p > 0.05);4.Binary Logistic regression analysis showed that the frequency of convulsion ≥ 3times and the duration of convulsion ≥ 10 min were independent risk factors for the increase of S100 B protein in the observation group.Conclusion:1.the expression level of S100 B protein in serum of children with convulsion is increased;2.In febrile convulsion group,the expression level of S100 B protein in serum of children with complex febrile convulsion was higher than that of simple febrile convulsion;3.there was no significant difference in the expression level of S100 B protein in serum of children with convulsions caused by different causes.4.the frequency of convulsion ≥ 3 times and the duration of convulsion ≥ 10 min were independent risk factors for the elevation of S100 B protein.