| Objective:The basis of this study The "influenza diagnosis and treatment plan(Revised Edition)" issued by the health committee in 2018 was formulated.The clinical efficacy of Shuang Hua Chai Qin powder,an empirical formula of Professor Sun Liping,was evaluated by randomized control principle,and the adverse reactions and safety after treatment were observed to clarify its clinical advantages,so as to provide reliable evidence-based medicine for the scientific treatment of influenza in children.Methods:Children with influenza-like symptoms admitted to the Pediatric Outpatient Department of the Affiliated Hospital of Changchun University of Chinese Medicine from November 2019 to December 2020 were selected in this study.Rapid antigen test of influenza virus was positive,and the inclusion and exclusion criteria were met as clinical subjects.All the patients were randomly divided into experimental group and control group.The experimental group was treated with Shuang Hua Chai Qin Powder combined with Oseltamivir Phosphate Granules,and the control group was treated with Xiao Er Chiqiao Qingre Granules combined with Oseltamivir Phosphate Granules.The other treatments were the same,with a treatment period of 5 days.During the treatment period,baseline characteristics,TCM syndrome scores,Western medicine symptom scores,laboratory tests and other conditions were observed and recorded in detail,and the test data were statistically analyzed using SPSS25.0 software.Results:Case Inclusion: A total of 100 clinical cases were collected in this clinical study.2cases were excluded,and the elimination rate was 2%;3 cases were exfoliated,and the rate of shedding was 3%.Finally,95 cases were included,including 48 cases in the experimental group and 47 cases in the control group.Baseline characteristic analysis: There were 95 patients,including 55 males and 40 females.There were 29 males and 19 females in the experimental group.The control group had 26 males and 21 females.Within one week before the onset of influenza,53 patients had clear contact history,33 patients had close contact,and 8 patients received influenza vaccine.There was no significant difference in the mean body temperature between the two groups before treatment.Analysis of treatment results: there were significant differences between the two groups in shortening the time of fever,alleviating the symptoms of systemic poisoning such as chills,headache and muscle soreness,and respiratory symptoms such as sneezing,sore throat,cough and sputum(P〈0.05),while there were no significant differences in the relief time of sweating,thirst,nasal congestion and runny nose.The decreasing range of TCM syndrome score and western medicine symptom score in the experimental group was significantly higher than that in the control group(P〈0.05),and there was no significant difference in the influence on parents.The clinical efficacy of the experimental group was significantly better than that of the control group(P〈0.05),and there was no significant difference in clinical cure.Safety assessment and analysis: in the test group,2 cases of abnormal laboratory test indicators and 2 cases of adverse reactions were found;There were 6 abnormal indicators and 3 adverse reactions in the control group,and there was no significant difference in medication safety between the two groups(P〉0.05).Conclusion:Shuang Hua Chai Qin Powder combined with Oseltamivir Phosphate Granulesr treatment of pediatric influenza clinical curative effect significantly better than control group,the specific performance in a completely antifebrile time,main symptoms,TCM syndrome integral,western medicine symptom integral,etc.,especially in relieving headache,body aches,sore throat,cough and other clinical symptoms was better than control group,with good security. |
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