Great Dragon Particle Treatment Of Common Cold (cold In The Heat Syndrome) Clinical Studies

Objective:Appraise the validity of Daqinglong Grain treating the upper respiratory tract infection (wind-cold exterior excess and gloomy fever syndrome) and the security of Daqinglong Grain. Methods:Adhibited the clinic examination of Positive Drug to Parallel Antitheses, two-blind random allocation, and polycentric. Finally analyzed the result by the statistic methods of the Evidence-based Medicine, the results showed using the therapeutic method of Daqinglong Grain (dispel the cold and clear away heat) to treat the upper respiratory tract infection (wind-cold exterior excess and gloomy fever syndrome) is have clinical validity and security, and it provided the basis to carry on the next clinic study and application .1. The clinical data based on 240 cases, which were divided into examination group and antitheses group , and both of them included 120 cases. The Various index signs of two groups' cases were validated by statistic methods (p>0. 05), which have no distinct differences and were comparable.2. Medicament usage: The remedial group took the Daqinglong Grain with boiled water, one bag (5g) once, three times a day, and the period of treatment was three days. The antitheses group took the Ganmao Qingre Grain with boiled water and with the same usage. In course of the experimentation couldn' t take other Chinese herbal medicine, each kind of antibiotics, febrifuge or anodyne, and etc, which might be influence the curative effect evaluation of the drugs.3. The observation of the curative effect and the security included two groups sufferers' body temperature, the time when had effect, the symptom and signs, the point of the various clinical symptoms before and after the treatments. The blood, urine, the liver and kidney function (ALT, BUN, SCR) and the electrocardiogram examinations were all needed before and after the treatments.4. The statistical analysis based on the SAS6. 12 statistical analytical software. All statistical tests based on the t test of two sides, and when P is small in or be equal to 0.05 were thought have the statistical meaning.Results:Compare with the main curative effect index signs of the two groups, which included the upper respiratory tract infection, the time when the medicine affect and defervesce the body temperature, the symptom and signs, the point of the various clinical symptoms, there was no statistical meaning. The blood, urine, the liver and kidney function and the electrocardiogram examinations before and after the treatments all hadn' t obvious change, which hinted the good security of the twogroups' medicine. Conclusions:The experiment adopted two-blind random allocation, Positive Drug to Parallel Antitheses, and polycentric clinical trial method , carry on the II period clinical trial to 240 testers by 5 clinical research centers, as a result, the curative effects of Daqinglong Grain and Ganmao Qingre Grain treating the upper respiratory tract infection (wind-cold exterior excess and gloomy fever syndrome) had no statistical difference , and the examination group had no badness affairs. Therefore it hinted Daqinglong Grain was a secure and effective medicament in treating the upper respiratory tract infection (wind-cold exterior excess and gloomy fever syndrome).