Study On The Correlation Between Multimodal Imaging Diagnosis And Molecular Subtypes Of Breast Cancer

Objective: To explore the correlation between imaging features of multi-modality imaging technology and different molecular types of breast cancer,and to find out the morphological features and ADC values of X-ray and MRI which are valuable in the prediction of different molecular typing,so as to provide more obejective basis for the basis for the diagnosis of breast cancer,making individualized treatment plan and improving prognosis.Methods: From October 2018 to February 2020,245 patients with breast cancer who were diagnosed by surgery or biopsy were collected.Before the opearation,mammography and magnetic resonance imaging were performed,and none of them received and radiotherapy and chemotherapy before the examination.According to pathological examination results,breast cancer patients were divided into four types,namely Luminal-A,Luminal-B,Her-2overexpression and triple negative type.The mammography and MRI images were evaluated according to the standard of Breast Imaging Reporting and Data System(BI-RADS).Results:Clinicopathological results showed that there was a moderate correlation between molecular classification and histological grade of breast cancer(C=0.41,P< 0.05).Luminal type and Her-2overexpression type were more common in type Ⅱ,and triple negative type was more common in grade Ⅲ.Image morphological features,including tumor maximum diameter,internal enhancement mode and calcitication classification,were moderately correlated with molecular classification of breast cancer,which tumor shape,burr,TIC curve and calcification were weakly correlated with molecular classification of breast cancer(P<0.05).The ADC average value of patients with negative ER and PR prognostic factors was higher than that of positive patients,and the ADC average value of patients with positive Her-2 was higher than negative patients(P<0.05),and the ADC average value of Her-2 overexpression was higher than other types.Conclusion: There are some differences in X-ray and MRI images of different molecular types of breast cancer.Mutimodal imaging technology can provide more scientific basis for selecting appropriate clinical treatment programs.