Study On The Correlation Between Dynamic Enhanced Magnetic Resonance And Molecular Typing Of Invasive Breast Cancer

Objective:To explore the characteristics of dynamic enhanced magnetic resonance imaging of invasive breast cancer and its correlation with molecular classification,and to guide clinical selection of appropriate treatment options.Methods: Retrospectively collect data of 57 patients with invasive breast cancer confirmed by surgery and pathology,and analyze the DCE-MRI imaging characteristics of the patients.According to the expression of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor-2(HER-2)and Ki-67 in tumor immunohistochemistry,breast cancer is divided into Luminal A Four subtypes: type,Luminal B type,Her-2 overexpression type,and triple-negative type,compare the dynamic enhanced MRI imaging characteristics and differences of different molecular subtypes of breast cancer.Results:Among 57 cases of breast cancer,Luminal A type accounted for 21.1%(12/57),Luminal B type accounted for47.4%(27/57),HER-2 overexpression type accounted for 17.5%(10/57),and triple negative breast cancer accounted for 14.0%(8/57).MRI of Luminal breast cancer often presents as irregular or lobulated masses.Triple-negative breast cancers often present with smooth edges and ring enhancements.Her-2 overexpression is more likely to appear as a fast-in and fast-out enhancement mode,namely type III TIC curve type.Conclusion:The morphological and hemodynamic characteristics of DCE-MRI of different molecular types of breast cancer have certain characteristics,which can assist in guiding clinical selection of treatment options and judging prognosis.