Correlation Between Tim-3/Galectin-9 Molecule And Clinicopathological Features Of Cervical Cancer

Objective:To investigate the expression and correlation of T cell immunoglobulin mucin-3(Tim-3)and galectin-9(Gal-9)in cervical cancer.Methods:from January 2018to September 2020,88 patients with IA-IIA cervical cancer(cervical cancer group),76patients with cervical squamous intraepithelial lesions(SIL group)and 58 patients with chronic cervicitis(chronic cervicitis group)were collected,Flow cytometry was used to detect the expression of Tim-3 on the surface of CD4~+T lymphocytes(CD4~+T)and Gal-9on the surface of monocyte(M)in peripheral blood of each group.The expression changes of Tim-3 and Gal-9 in peripheral blood of each group were compared,and the correlation between the expression differences of Tim-3 and Gal-9 and the clinicopathological features of cervical cancer patients was analyzed.Results:compared with SIL group and chronic cervicitis group,the expression levels of Tim-3~+CD4~+T and Gal-9~+M in cervical cancer group were significantly increased(P<0.05);The expression levels of Tim-3~+CD4~+T and Gal-9~+M in peripheral blood of patients with lymph node metastasis and poorly differentiated cervical cancer were significantly higher than those of patients with well differentiated cervical cancer and no lymph node metastasis(P<0.05).The expression levels of Tim-3~+CD4~+T and Gal-9~+M in peripheral blood of patients with cervical cancer after operation were significantly lower than those before operation(P<0.05).Conclusion:Tim-3/Gal-9 is related to the progression of cervical cancer,and its expression level is correlated with pathological grade and lymph node metastasis,and the expression level is decreased after operation.Therefore,Tim-3/Gal-9 may be one of the indicators to evaluate the prognosis of patients with cervical cancer.