Regular Pattern And Meta Analysis Of Traditional Chinese Medicine In Treating Impaired Glucose Tolerance

Objectives:By collecting clinical research literature on the treatment of IGT in Chinese medicine,summary and analysis the regularity;Use Meta-analysis to objectively evaluate the clinical efficacy of the prescriptions for replenishing qi and nourishing yin in the treatment of IGT,so as to provide reference and evidence-based basis for TCM treatment of IGT.Methods:Use the computer network to retrieve clinical research literature about IGT,and use Excel2019 to statistically analyze the frequency and frequency composition ratio of commonly used drugs.2.On the basis of the first part,the relevant literature of clinical randomized controlled studies on the treatment of impaired glucose tolerance with replenishing qi and nourishing yin prescriptions was further screened.The risk assessment form in the Cochrane Handbook was used to evaluate the quality of the included studies,and Note Express was used for document management.Excel2019 summarizes the extracted information and data.Rev Man5.3software was used to process and analyze the data,draw a forest map,and systematically evaluate the effect and safety of replenishing qi and nourishing yin Recipe in treating impaired glucose tolerance.Results:1.Data extraction of Chinese medicines used in 102 articles included,there are 137 kinds of Chinese medicines,and the total frequency is 948 times.The drugs with a frequency of more than 7times are commonly used drugs,a total of 42 kinds,the frequency and composition ratio from high to low are Poria(42,4.43%),Astragalus(38,4.01%),Coptis(38,4.01%)and so on.42 kinds of commonly used medicines are classified according to the efficacy of traditional Chinese medicine,and belong to 17 kinds of medicines,with a total frequency of 715 times.Tonic drugs(245,34.27%)have accumulated the most frequency of use,followed by antipyretic drugs(172,24.06%),and the composition ratio of other types of drugs was all below 10%.2.15 articles were included to conduct a Meta-analysis on the effective rate and outcome of replenishing qi and nourishing yin prescriptions in the treatment of IGT: In the traditional Chinese medicine treatment group,the effective rate [the combined effect value of the RR value is 1.92,and the confidence interval is 95 The range of% is [1.69,2.19],P<0.00001] and the return to normal rate [RR=2.90,95%CI(2.29,3.68),P<0.00001],the difference is statistically significant,indicating that the Chinese medicine treatment group has better efficacy.Meta-analysis of replenishing qi and nourishing yin Recipe on blood glucose related indicators:The combined effect size of fasting blood glucose MD is 0.30,and its 95% CI is [0.07,0.52],P<0.05;2h postprandial blood glucose[MD=0.93,95% CI(0.55,1.32),P<0.0001];Hb A1C[The combined effect size is 0.31,and the estimated range is [0.26,0.35]according to the 95% confidence interval,P<0.00001],indicating that the blood glucose improvement of the treatment group is better than that of the control group.Meta analysis of replenishing qi and nourishing yin prescriptions on IGT insulin-related indicators:insulin(fasting)[MD value=1.17,95% confidence interval between0.35 and 2.00,P=0.005];insulin(2h)[combined effect size The value is 7.73,the confidence interval range is 1.60-13.85,P=0.01],indicating that the insulin improvement of the treatment group is better than that of the control group.Meta analysis of traditional Chinese medicine on IGT body mass index: [MD=1.42,95%CI(0.52,2.32),P=0.002],the improvement of BMI in the treatment group was better than that in the control group.In terms of adverse reaction reports,there is no significant difference between the use of replenishing qi and nourishing yin Recipe and lifestyle intervention alone.Conclusion:1.IGT’s traditional Chinese medicine treatment is mainly to invigorate the spleen,but the clinical syndromes are diverse,and there are many types of drug effects.The first three are tonic(mainly for qi and yin),clearing heat,and diuresis and dampness medicine.2.The effective rate of prescription for replenishing qi and nourishing yin in treating IGT was better than that of control group,which could delay the progress of IGT to DM,and reduce the blood sugar,fasting insulin,2h insulin and body mass index of IGT patients,without obvious adverse reactions.