Clinical Efficacy Of Jiu Wei Gu Jin Capsule In The Treatment Of Chronic Obstructive Pulmonary Disease With Deficiency Of Lung And Kidney At Stable Stage

Objective: to evaluate the clinical efficacy,pulmonary function and the influence of T cell subsets in peripheral blood by analyzing the difference between the treatment group(Jiuwei Gujin capsule combined with tiotropium bromide powder inhalation powder)and the control group(tiotropium bromide powder inhalation spray)in(COPD)stable phase,so as to provide scientific theoretical basis for clinical application,better guide clinical practice,and provide clinical basis for later experimental research.Methods: According to the standard of excretion in the study design,88 patients with stable chronic obstructive pulmonary disease diagnosed in the outpatient and inpatient departments of Shanxi Hospital of traditional Chinese Medicine from December 2019 to December 2020 were strictly collected in accordance with the syndrome of deficiency of both lung and kidney in traditional Chinese medicine(TCM).There were 44 cases in the control group and 44 cases in the treatment group.During the trial,2 cases in the control group fell off,and a total of 86 cases were involved in the statistical analysis.The control group was treated with tiotropium bromide powder inhalation powder,and the treatment group was treated with Jiuwei Gujin capsule(composed of Cordyceps cephalosporin powder,Gekko gecko,Dilong,Schisandra,Fructus Xanthii,Fructus Corni,yam and licorice).The long-term effect was evaluated comprehensively after 90 days of treatment.The efficacy of clinical treatment,pulmonary function,TCM symptom score,quality of life St.George respiratory questionnaire(SGRQ)score,m MRC respiratory disorder difficulty scale,CAT evaluation scale,6-minute walk test and T lymphocyte immune function index of peripheral blood were compared.During the test,the physical signs of the patients were analyzed and observed to determine the existence of adverse reactions and further carry out safety evaluation.Results:Results: in the course of this study,2 patients in the control group fell off,a total of 86 patients completed clinical observation and the clinical data were valid.1.After the treatment,the effective rate of the treatment group and the control group in the efficacy of TCM symptoms was 95.45% and 80.95%,respectively.After analysis,P=0.00<0.01 was statistically significant,indicating that the treatment group had an advantage over the control group in the efficacy of TCM symptoms.2.TCM symptom score: there was significant difference between groups before treatment(P>0.05).After treatment,the TCM symptom score of the treatment group was significantly lower than that of the control group(P<0.05).The results show that the combination of Jiuwei Gujin capsule can improve the symptoms of TCM,such as cough,asthma,expectoration,easy to catch cold,sore waist and knees and so on.3.Comparison of pulmonary function: there was significant difference between groups before treatment(P>0.05).After treatment,the FEV1 and FEV1/FVC of the treatment group were significantly better than those of the control group.It shows that the combination of Jiuwei Gujin capsule can improve the lung function of patients.4.Each score scale: there was significant difference among groups before treatment(P>0.05).After 3 and 6 months of treatment,the SGRQ score,m MRC dyspnea scale and CAT score of the two groups were lower than those before treatment,while the 6-minute walking test was higher than that before treatment,and the improvement effect of the treatment group was better than that of the control group.The results show that the combination of Jiuwei Gujin capsule can improve the clinical symptoms of the patients,and the long-term effect is good.5.Laboratory indexes: the three indexes of T cell subsets in the two groups were all P >0.05 before treatment,but there was no significant change in CD4+ and CD8+ in the two groups after 1 month treatment,but the ratio of CD3+ and CD4+/CD8+ increased(P<0.05).After 3 months treatment,the levels of CD3,CD3+CD4+ and CD4+/CD8+increased and CD3+CD8+ decreased,and the improvement effect of the treatment group was better than that of the control group(P<0.05).It is suggested that Jiuwei Gujin capsule can regulate T cell subsets in patients with kidney qi deficiency syndrome in stable stage of COPD,strengthen the immune function of patients,and reduce the frequency of disease aggravation.6.The two groups of patients had no discomfort symptoms during the treatment;after treatment,the laboratory safety indicators(blood cell analysis,biochemical examination)were not abnormal,and the ECG was not abnormal.It is suggested that the two therapeutic effects of this study are safe and effective.Conclusion: Jiuwei Gujin capsule combined with tiotropium bromide powder inhalation powder spray has significant effect in the treatment of stable COPD with lung and kidney qi deficiency syndrome.It can better relieve the patients’ cough,expectoration,asthma,waist and knee soreness,easy to catch a cold and other TCM clinical symptoms,relieve the symptoms of dyspnea,increase activity tolerance,improve lung function,increase CD3 +,CD4 + levels,reduce CD8 +,improve the patient’s immunity,and the long-term effect is good.There was no adverse reaction.