| Objective: To collect and analyze the clinical research literatures on the treatment of sequelae of pelvic inflammatory diseases with traditional Chinese medicine published in recent 10 years(January 1,2010,solstice,December 31,2019)and meeting the inclusion criteria by CNKI database,and use relevant statistical software to dig out the rules of drug formulation for the treatment of sequelae of pelvic inflammatory diseases with traditional Chinese medicine,in order to provide perfect literature materials for the treatment of sequelae of pelvic inflammatory diseases with Chinese medicine.Methods:The China National Knowledge Network(CNKI)database was used to search the clinical research literatures on the treatment of sequelae of pelvic inflammatory diseases with traditional Chinese medicine published in recent 10 years(January 1,2010-February 31,2019).According to the inclusion criteria and exclusion criteria,the literatures that met the requirements of this study were finally screened out,and the relevant information in the literatures was extracted one by one;and input into Epi Date3.1software to establish a database,and then the data in the database are normalized and collated,and the basic situation of the literature is analyzed by metrology.Use of auxiliary platform(V2.5)software excavated drug basic information(frequency of drug,drug classes,four gas mixed,drug combination,commonly used drugs,core drug combination and the new process combination information),and the related information to make a basic discussion,it summarized the drug prescription of traditional Chinese medicine treatment of pelvic inflammatory disease sequelae.Results:Literature information: According to the retrieval strategy,a total of 6,242 literatures were retrieved from CNKI,and 188 literatures meeting the requirements were finally screened according to the inclusion and exclusion criteria,among which a total of17,927 cases were reported.Through analysis,it was found that the number of literatures published in 2017 was the largest(30 articles),accounting for about 15.96% of the total literatures,and the number of literatures published in 2014 was the least(9 articles),accounting for about 4.79% of the total literatures.Among the 188 literatures,172 literatures were journals(91.49%)and 16 literatures were dissertations(8.51%).Among the 172 journals,13 were core journals,accounting for 16.67% of the total number(78),and 65 were non-core journals,accounting for 83.33% of the total.Among the 172literatures,18 literatures(9.57%)were supported by the fund.Shandong Province had the largest number of published literatures,with a total of 19(10.11%).The number of published literatures varied greatly according to the regions,with the southern region being more than the northern region,the eastern region being more than the western region.Treatment: In the 188 literatures,the age of patients was mainly distributed between20 and 45 years old(accounting for 64.5% of the total number of patients).In the literatures,the treatment time of the control group and the treatment group(observation group or experimental group)was 30 days,a total of 50 literatures,accounting for 26.59%of the total number of literatures.In terms of medication,the treatment group(the observation group or the experimental group)was given decoction or Chinese patent medicine alone,while the control group was mainly divided into western medicine,Chinese patent medicine,Chinese traditional medicine decoction and placebo group,among which western medicine was the most,with a total of 99 articles,accounting for about 52.6% of the total literature.Among western medicines,metronidazole combined with levofloxacin was the most frequently used,with a total of 33 papers,accounting for33.33% of the total number in the western medicine group.The proportion of western medicine containing metronidazole was the highest,with a total of 63 papers,and the frequency of occurrence in western medicine was 63.63%.The most frequently used Chinese patent medicine was Gynecology Qianjin Tablet(37 articles),accounting for44.04% of the total use of Chinese patent medicine.Three types of efficacy evaluation indexes were applied in 188 literatures,and symptom integral method of TCM was the most widely used,which was involved in 173 literatures(97.87%).Clinical symptoms and signs were the most commonly used indicators,and 184 literatures(97.87%)were involved.The effective rate of the treatment group was mainly distributed between 90% and 99.99%,accounting for about 85.10% of the total literature.The effective rate of the control group was mainly distributed between 80% and 89.99%,accounting for 47.34% of the total literatures.Adverse reactions were found in 12 of the 188 literatures,accounting for 6.83%of the total literatures,and recurrence occurred in 11 literatures,accounting for 12.5% of the total literatures.Syndrome differentiation: In the 188 literatures,19 syndromes were obtained after the standard treatment of syndromes.Is hot and damp stasis respectively by 63(33.51%),45(23.94%),qi and blood stasis and dampness grinds the article 18(9.57%),15 of qi deficiency and blood stasis syndrome(7.98%),blood stasis,10(5.32%),blood stasis,heat exchange by article 7(3.72%),haemorrheological nature 6 piece of blood stasis syndrome(3.19%),wet stasis mutual junction 3 article(3.19%),hot and humid card within 4(2.13%),liver and spleen discord certificate 2(1.06%),Yang deficiency and blood stasis syndrome(1.06%),2 cold dampness stasis and 2(1.06%),blood deficiency syndrome(1.06%),2 1paper with kidney deficiency and liver stagnation syndrome(0.05%),1 paper with spleen deficiency and dampness obstruction syndrome(0.05%),1 paper with positive qi and Yin deficiency syndrome(0.05%),1 paper with liver stagnation and blood deficiency syndrome(0.05%),1 paper with liver stagnation and spleen deficiency syndrome(0.05%),and 1 paper with heat toxin stagnation syndrome(0.05%).Drug use: Among the 188 included literatures,a total of 235 traditional Chinese medicines were collected,and the cumulative frequency of drug use was 2142 times.Classified according to the efficacy of traditional Chinese medicines,thermal-clearing drugs were used the most frequently,444 times in total,accounting for 20.73% of the total frequency.It was followed by 419 times(19.56%)for promoting blood circulation and removing blood stasis,390 times(18.21%)for tonifying deficiency,236 times(11.01%)for promoting water and moistening dampness,and 206 times(9.62%)for regulating qi.According to the classification of the five flavors of traditional Chinese medicine,bitter drugs were used the most(1,181 times),accounting for 39.66% of the total times,followed by sweet drugs 835 times(28.04%)and spicy drugs 810 times(27.20%).According to the analysis of drug channeling,liver channel was the most frequent channel channeling,with a total of 1292 times,accounting for about 25.81% of the total number of drug channeling.It was followed by spleen meridians(844 times)(16.86%),heart meridians(724 times)(14.47%)and stomach meridians(10.29%).The drugs classified into trijiao meridian,small intestine meridian and pericardium meridian were the least frequent.Treatment of pelvic inflammatory disease sequelae of high frequency drugs Angelica,red peony,peach kernel,Salviae miltiorrhiza,Qiici seed,Yanhusuo,Xiangfu,Chuanxiong,Zhilicorice and so on.High-frequency drug combinations are "Angelica,Chuanxiong","Angelica,red peony root","red peony root,peach kernel","red peony root,chuanxiong","red peony root,red miltiorrhiza miltiorrhiza","herb herb,coix seed".The core drug combination includes10 medicines(Angelica sinensis,Fructus sinensis,Radix Paeoniae Radix,Salvia miltiorrhiza,Peach kernel,Radix Danpi,Radix Aminoides,Ligusticum chuanxiong,Radix Glycyrrhizae,Coix seed).Seven new formulae were obtained based on entropy cluster analysis.Conclusion: Nearly 10 years of traditional Chinese medicine in the treatment of pelvic inflammatory disease sequelae research literature of the number of years have small amplitude fluctuation,but on the whole,tend to be relatively stable,related journals published more scattered,uneven(province)of research region,main characteristic is the southeast area,northwest area is little,perhaps the main cause is the northwest less human resources and financial support.At present,the common witness types of the sequelae of pelvic inflammatory diseases are the syndrome of dampness-heat stasis,qi stagnation and blood stasis,cold dampness stagnation and qi deficiency and blood stasis.In terms of drug use,the main drugs are heat clearing,blood circulation and stasis removing drugs and deficiency tonic drugs.In the treatment and pelvic inflammatory disease sequela of the pathogenesis of the same characteristics.Cluster analysis of 235 traditional Chinese medicines was carried out by using the software of TCM Inheritance Assist Platform(V2.5),and a total of 14 pairs of core drug combinations and 7 new prescriptions for the treatment of sequelae of pelvic inflammatory diseases were obtained.It was found to be consistent with the pathogenesis of the disease through analysis of its regularity. |
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