| Objective:This project is to evaluate the therapeutic effect of yunpi huatan decoction combined with conventional western medicin e on the blood pressure level of patients with phlegm-dampness-resi stant refractory hypertension before and after the use of TCM syndr ome score blood pressure variability and other clinical indicators,so as to provide ideas for the combination of traditional Chinese and western medicine in the treatment of refractory hypertension and t he reduction of target organ damageMethods:This project included 60 patients who voluntarily participated in this study and signed informed consent from October 2018 to November 2019,who were diagnosed as refractory hypertension in accordance with the European hypertension guidelines for 2018,and who met the diagnostic criteria of traditional Chinese medicine(TCM)for vertigo and phlegm-dampness resistance in clinical research guidelines for new Chinese medicine.They were randomly di-vided into two groups.Control group are giving irbesartan,nifedipine controlled release tablets and hydrochlorothiazide were administered.Treatment group:on the basis of the control group plus administrati-on of yunpi huatan decoction plus reduction.The two groups were treated continuously for 4 weeks.They filled in the TCM symptom score,recorded blood pressure and and 24-hour dynamic blood pres-sure.SPSS23.0 statistical software was used to analyze the data of related indicators To observe the effect of yunpi huatan decoction combined with the western medicine recommended in the guidelines on the clinical efficacy indexes of refractory hypertension with moderate resistance to phlegm and dampness.Results:1.Blood pressure level:there was no statistically significant difference in the reduction of systolic and diastolic blood pressure in the control group after treatment(P>0.05);the systolic and diastolic blood pressure in the treatment group after treatment decreased compared with that before treatment,with statistically significant difference(P<0.05);and the systolic and diastolic blood pressure in the treatment group was lower than that in the control group after treatment,with statistically significant difference(P<0.05).2.Blood pressure efficacy:the total effective rate of the treatment group was 79.31%and 35.72%,respectively,with significant difference between the two groups(P<0.01).3.Curative effect of TCM syndrome:the total effective rate of the treatment group and the control group was 93.1%and 42.86%,respectively,with significant difference between the two groups(P<0.01).4.Total score of TCM syndromes:the total score of syndromes in the two groups after treatment was lower than that before treatment,with significant difference(P<0.01),and the reduction degree in the treatment group was better than that in the control group,with significant difference(P<0.01).5.Single score of TCM syndromes:after treatment,all syndromes in the treatment group were lower than before treatment,with significant difference(P<0.01).After treatment,the score of vertigo and headache in the control group was lower than that before treatment,with significant difference(P<0.01).The score of head,chest tightness,palpitation,acratia,loose stool and loose food syndrome had no significant difference compared with that before treatment(P>0.05).After treatment,the scores of various syndromes in the treatment group were lower than those in the control group,with significant difference(P<0.01).6.Blood pressure variability:after treatment,the standard deviation of 24h systolic blood pressure(24hsbp-sd)24h diastolic blood pressure(24hdbp-sd)day systolic blood pressure(dsbp-sd)day diastolic blood pressure(ddbp-sd)night systolic blood pressure(nsbp-sd)night systolic blood pressure(ndbp-sd)in the two groups decreased,showing a statistical difference(P<0.05).The decrease of 24hdbp-sd was better than that of the control group,and there was a statistical difference(P<0.05).There was no statistically significant difference between the remaining indicators(P>0.05).Conclusion:This study proves that yunpi Huatang combined with conventional western medicine in the treatment of phlegm-dampness type refractory hypertension can effectively reduce the blood pressure level and improve the related TCM clinical syndromes,and at the same time effectively improve the role of blood pressure variability,compared with the use of western medicine alone can better maintain the stability of blood pressure.No adverse reactions occurred in both groups during the treatment,which is safe for clinical use and can be further studied and promoted. |
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