| Objective:In this study,we established a colorectal polyp database by cooperating with a professional data management company.This database was used to explore the clinical characteristics of colorectal polyps,the relationship between polyp pathological type,polyp quantity and TCM syndrome type,and to analyze the influencing factors of adenomatous polyps and multiple polyps.Methods:(1)Construction of database:by referring to the relevant literature at home and abroad,combining with the characteristics of colorectal polyps,according to the clinical and scientific research needs,design and develop the information collection questionnaire including the clinical characteristics of traditional Chinese and Western medicine,in order to collect the patient’s personal history and family history,basic information,clinical manifestation,specialized diagnosis and treatment information,traditional Chinese medicine diagnosis and treatment information,laboratory and auxiliary examination and other clinical data.The team put forward the design requirements according to the needs of clinical scientific research,through cooperation with the database production company,based on Browser/server(B/s)structure mode,using java＋Apache Tomcat 8+MySQL golden combination software method for data development and testing,and finally built the colorectal polyp database.(2)Application of database:since July 2019,the clinical data of Chinese and Western medicine of some colorectal polyp patients in outpatient and inpatient of University City Hospital of Guangdong traditional Chinese medicine have been entered into the database.Using the functions of database retrieval,statistics and data export to analyze the clinical data of patients,explore the clinical characteristics of colorectal polyps,analyze the influencing factors of adenomatous polyps and multiple polyps,and explore the relationship between pathological types,polyp quantity and TCM syndrome types.Results:(1)Built database:a colorectal polyp database with the characteristics of integrated traditional Chinese and Western medicine has been preliminarily established.The database has the functions of data storage,query,statistics,export,information sharing,teaching,etc.the page is simple,the function is complete,the operation is good,and it can meet the needs of clinical and scientific research work of colorectal polyps.(2)Preliminary application:use the database to analyze the clinical data of the cases.1.Gender distribution:the database includes 89 patients,55 males and 34 females,with the ratio of male to female being 1.62:1.2.Age distribution:the age range is 23-67 years old,the average age is 50.49 ± 10.45 years old,and the high incidence age is mainly 40-69 years old,accounting for 87.6%.There were 3 cases aged 20-29,8 cases aged 30-39,24 cases aged 40-49,32 cases aged 50-59 and 22 cases aged 60-69.3.BMI distribution:BMI range is 15.57-34.67kg/m2,average BMI:23.40 ±3.90kg/m2.BMI was mainly concentrated in 18.5-27.9kg/m2,accounting for 78.7%.9 cases had BMI<18.4kg/m2,42 cases had BMI<23.9kg/m2,28 cases had BMI<27.9kg/m2,10 cases had BMI≥ 28kg/m2.4.Main symptoms:abdominal distention in 31 cases(34.8%),diarrhea in 25 cases(28.1%),abdominal pain in 24 cases(27%),constipation in 16 cases(18%),hematochezia in 4 cases(4.5%),feeling of incomplete defecation in 4 cases(4.5%),and asymptomatic in 17 cases(19.1%).5.Distribution of TCM syndrome types:41 cases(46.1%)of stagnation of dampness and blood stasis,37 cases(41.6%)of spleen deficiency and stagnation of blood stasis,11 cases(12.4%)of dampness and heat of intestine,and 0 cases of qi stagnation and blood stasis.6.The number of polyps:43(48.3%)with single polyp,24(27.0%)with 2-3 polyps,7(7.9%)with 4-5 polyps,6(6.7%)with 6-9 polyps,and 9(10.1%)with 10 or more polyps.7.Polyps:20(22.5%)were rectal polyps,45(50.6%)were sigmoid polyps,22(24.7%)were descending polyps,36(40.4%)were transverse polyps,18(20.2%)were ascending polyps,and 7(7.9%)were ileocecal polyps.8.Polyp size:21 cases(23.6%)with diameter≤5mm,45 cases(50.6%)with diameter 6-10 mm,23 cases(25.8%)with diameter≥11 mm.9.Polyp Yamada classification:type I in 8 patients(9.0%),type II in 49 patients(55.1%),type III in 21 patients(23.6%).Type Ⅳ 11 cases(12.4%).10.Pathological types:tubular adenoma in 59 cases(72.8%),hyperplastic polyp in 17 cases(21.0%),inflammatory polyp in 2 cases(2.5%),serrated adenoma,tubular villous adenoma and intramucosal carcinoma in 1 case(1.2%).11.There was no significant difference in the distribution of TCM syndromes between adenomatous polyps and non-adenomatous polyps(P>0.05).12.There was no significant difference in the distribution of TCM syndromes between multiple polyps and single polyps(P>0.05).13.The distribution of syndrome elements of disease location:spleen 49 cases(55.06%),stomach 35 cases(39.33%),large intestine 12 cases(13.48%),liver 11 cases(12.36%).14.The distribution of syndrome elements of disease nature:dampness 82 cases(92.13%),phlegm 73 cases(82.02%),Qi deficiency 53 cases(59.55%),qi stagnation 48 cases(53.93%),Yang deficiency 40 cases(44.94%),blood stasis 29 cases(32.58%).15.There was no significant difference in the distribution of syndrome elements of disease location between adenomatous polyps and non-adenomatous polyps(P>0.05).16.There was no significant difference in the distribution of syndrome elements of disease nature between adenomatous polyps and non-adenomatous polyps(P>0.05).17.Analysis of the influencing factors of adenomatous polyp:the size of polyp affected the incidence of adenomatous polyp.The detection rate of adenomatous polyp in the group with polyp size ≥ 6mm was significantly higher than that in the group with polyp size≤5mm(79.4%vs 33.3%).The difference was statistically significant(P<0.05).Gender,age,BMI,drinking history,smoking history,long-term medication history did not affect the incidence of adenomatous polyps,the difference was not statistically significant(P>0.05).18.Analysis of the influencing factors of multiple polyps:age has a statistical significance(P<0.05).BMI,gender,drinking history,smoking history,polyp size,long-term medication history did not affect the incidence of adenomatous polyps,the difference was not statistically significant(P>0.05).Logistic regression analysis showed that age(P＝0.014,OR＝1.057)was the risk factor of multiple polyps.Conclusion:1.The colorectal polyp database can store,sort,retrieve,analyze and export the diagnosis and treatment data of patients with colorectal polyps in Chinese and Western medicine,provide important case resources for in-depth study of colorectal polyps,lay the foundation for exploring the diagnosis and treatment plans of colorectal polyps in traditional Chinese and Western medicine,and is a powerful tool for clinical and scientific research work of digestive physicians.2.Colorectal polyps are more common in men than in women.The age of high incidence is 40-69 years old.BMI is 18.5-27.9kg/m 2.The main symptoms are abdominal distention,diarrhea,abdominal pain,constipation,etc.the syndrome types of traditional Chinese medicine mainly include dampness stasis block syndrome and spleen deficiency with stasis syndrome.The number of polyps is mostly less than 3,mostly 6-10 m m in size,mostly in sigmoid colon and transverse colon,and most in Yamada,The main pathological types were tubular adenoma and hyperplastic polyp.3.Spleen,stomach,dampness and phlegm are the core syndrome elements of colorectal polyps,and large intestine,Qi deficiency,qi stagnation,Yang deficiency and blood stasis are the important components.4.Adenomatous polyps are more likely to occur when the polyp size is ≥6mm.Age is a risk factor for multiple polyps. |
