Risk Factors Of Colorectal Polyps And Their Effects On Pathological Types Of Colorectal Polyps

Objective: This study retrospectively analyzed the risk factors of colorectal polyps,explored the risk factors of colorectal polyps and their effects on the pathological types of polyps,and provided a theoretical basis for the early screening and prevention of colorectal polyps,so as to reduce the incidence and mortality of colorectal cancer.Methods: 1.According to the inclusion and exclusion criteria,202 hospitalized patients who underwent gastrointestinal endoscopy in the endoscopy center of Nanxishan hospital of Guangxi Autonomous Region from August 2020 to August 2021 were collected.2.202 patients were divided into colorectal polyps group and control group according to the presence or absence of polyps by colonoscopy.All polyps were examined by biopsy and pathological examination.To further understand the risk factors of colorectal polyps and their effects on the pathological types of polyps,we will discuss the effects of gender,age,weight,body mass index,smoking history,drinking history,triglyceride,total cholesterol,low density lipoprotein cholesterol,uric acid,type 2diabetes,Helicobacter pylori infection,gastric polyps,hypertension,coronary heart disease,cerebral infarction,nonalcoholic fatty liver disease on colorectal polyps retrospectively.Results: 1.Through the analysis of the basic data of the colorectal polyp group and the control group,the results showed that the polyp detection rate of gender(P=0.170),smoking history(P=0.141),drinking history(P=0.059),coronary heart disease(P=0.064)was higher than that of the control group,but the difference was not statistically significant.Patients with type 2diabetes mellitus(P=0.025),helicobacter pylori infection(P<0.001),gastric polyp(P<0.001),hypertension(P<0.001),cerebral infarction(P<0.001),and nonalcoholic fatty liver disease(P<0.001),Their colorectal polyp detection rates were higher than those without these diseases,and the difference was statistically significant.2.The age,body mass index(BMI),triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and uric acid levels of the colorectal polyps group and the control group were compared and analyzed.The results showed that the BMI,TG,and TC levels of the colorectal polyps group were higher than those of the control group,but the difference was not statistically significant(P>0.05).Age,low density lipoprotein cholesterol,uric acid levels were significantly higher than those in the control group,and the differences were statistically significant(P<0.001).3.Univariate logistics regression analysis showed that age,uric acid,low-density lipoprotein cholesterol and type 2diabetes mellitus were used as variables,and the odds ratios were1.146,1.009,2.201 and 2.788,respectively,and the differences were statistically significant(P<0.05).4.The odds ratio(OR)of Helicobacter pylori infection,gastric polyps and non-alcoholic fatty liver disease as variables were 11.076,12.286 and 9.503,respectively,and the differences were statistically significant(P<0.01).There was no significant difference in the incidence of colorectal polyps between patients with cerebral infarction and patients with colorectal polyps.5.Factors with P<0.05 obtained by univariate logistics regression analysis were further included in multivariate binary logistics regression analysis.The probability of developing colorectal polyps was 1.151 times(OR=1.151,95%CI:1.065-1.243,P<0.001)for each 1 year increase in age.Patients with Helicobacter pylori infection were 10.497 times more likely to have colorectal polyps than those without Helicobacter pylori infection(OR=10.497,95%CI:1.196-92.117,P=0.034).Patients with gastric polyps were 35.768 times more likely to have colorectal polyps than patients without gastric polyps(OR=35.768,95%CI:3.511-364.409,P=0.003).6.Chi-square test showed that the incidence of adenomatous polyps in patients with type 2 diabetes mellitus was higher than that in patients without type 2 diabetes mellitus,P=0.017,and the difference was statistically significant.7.The pathological type of colorectal polyps and the duration of type 2 diabetes mellitus were compared by chi-square test.With the prolongation of the duration of type 2 diabetes mellitus,the risk of adenomatous polyps increased(χ 2 =9.574,P=0.008).8.The levels of low-density lipoprotein cholesterol and blood uric acid in adenomatous polyps group were higher than those in non-adenomatous polyps group,and the average age in non-adenomatous polyps group was older than that in adenomatous polyps group,but the differences were not statistically significant(P>0.05).The incidence of adenomatous polyps was higher than that of non-adenomatous polyps after combined with Helicobacter pylori infection,gastric polyps,cerebral infarction and non-alcoholic fatty liver disease,but the differences were not statistically significant(P>0.05).Conclusions: 1.Helicobacter pylori infection,gastric polyps,age,type 2 diabetes mellitus,uric acid,low density lipoprotein cholesterol,cerebral infarction and non-alcoholic fatty liver disease are the risk factors for colorectal polyps.Among them,Helicobacter pylori infection,gastric polyps and age are the independent risk factors for colorectal polyps.2.The risk of colorectal polyps in patients with type 2 diabetes mellitus is increased.The colorectal polyps in patients with type 2 diabetes mellitus are mainly adenomatous polyps.With the prolongation of the duration of type 2 diabetes,the incidence of adenomatous polyps is higher.3.Patients who combined with helicobacter pylori infection,gastric polyps,nonalcoholic fatty liver disease,cerebral infarction,elevated uric acid levels,and elevated low-density lipoprotein cholesterol levels,the possibility of adenomatous polyps will increase.