Clinical Observation Of Zhiyan Xiaoji Prescriptions In The Treatment Of Primary Hepatocellular Carcinoma

Background: Primary liver cancer(Primary lever cancer,PLC,referred to as liver cancer)is a major disease that seriously endangers human life and health at present.The mortality rate of liver cancer ranks the second in the mortality rate of malignant tumors in our country.The onset of liver cancer is hidden,most of the patients are in the middle and late stage,and they have lost the opportunity of surgical treatment.The curative effect of traditional Chinese medicine in the treatment of liver cancer is unique,which is not only the characteristic of liver prevention and treatment in our country,but also an important part of multidisc-ciplinary treatment of liver cancer in our.Zhiyan Xiaoji Prescriptions is a prescription for the treatment of hepatobiliary damp-heat type liver cancer in our research group,and it has been used in clinic for more than 6 years.At present,the main clinical application mode of this prescription is Zhiyan Xiaoji Prescri-ptions combined with hepatic artery chemoembolization(Transcatheter arterial chemoembolization,TACE)and oral Zhiyan Xiaoji Prescriptions.This paper summarizes the therapeutic effect of the above two models of Zhiyan Xiaoji Prescriptions.Objective: To retrospectively observe the clinical effect of Zhiyan Xiaoji Prescriptions and its combination with TACE in the treatment of advanced liver cancer of damp-heat type of liver and gallbladder,so as to provide basis for further clinical study of Zhiyan Xiaoji Prescriptions.Participants and methods: Retrospective analysis was performed on the clinical data of 53 patients with primary liver cancer treated in outpatient or inpatient treatment in the Affiliated Cancer Hospital of Guangxi Medical University from January 2016 to March 2019.All patients were admitted to our hospital,including 47 patients who had not received surgery,intervention,targeting,chemoradiotherapy or other anti-tumor therapy before admission,and6 patients who had recurrence or metastasis after multiple treatments.The TCM syndrome differentiation type is hepatobiliary damp-heat type.According to different treatment modes,the included cases were divided into the TCM treatment group and the TCM +TACE treatment group,including 29 cases in the TCM group and 24 cases in the TCM +TACE group.The traditional Chinese medicine group was given the decoction of Zhiyan Xiaoji Prescriptions,190 ml each time and twice a day.At the same time according to the situation to protect the liver,pain,diuretic and other basic treatment.The traditional Chinese medicine +TACE group was given oral administration of the traditional Chinese medicine Zhiyan Xiaoji Prescriptions(the same usage as the traditional Chinese medicine group)before TACE operation,and no other anti-tumor therapy was given except basic treatment.Objective efficacy,behavioral status,body weight,liver function,and liver cancer related symptoms were evaluated after 3 months of continuous treatment.Fifty-three patients were followed up regularly and the6-month and 1-year survival rates were calculated.SPSS26.0 software was used for statistical analysis.Continuous variables were expressed as mean ± standard deviation(x±s),and comparison was performed by T test.Descriptive analysis of categorical variables was expressed as frequency or percentage,and chi-square or Fsher test was used for comparison.The survival curve was drawn by Kaplan-Meier method,and the difference between the groups was compared by log-rank.P < 0.05 was considered statistically significant.Results: Kaplan-meier method was used to compare the therapeutic effects of the two treatment modes on advanced hepatocellular carcinoma with dampness and heat of liver and gall.The results indicated that the OS of the Chinese medicine group and the Chinese medicine +TACE group were 6.5months and 21.3 months respectively,and the log-rank test showed that P=0.012.The half-year survival rate was 51.72% in the TCM group and 75.00%in the TCM +TACE group,and the 1-year survival rate was 31.03% and 62.50%in the TCM +TACE group,respectively.Objective efficacy of TCM group:tumor remission rate was 11.11%,disease control rate was 70.37%.Objective efficacy of TCM +TACE group: tumor remission rate was 42.11%,disease control rate was 78.94%.After the treatment with Chinese medicine and Chinese medicine +TACE,the KPS score in both groups increased compared with that before treatment,and there were significant statistical differences(P=0.018<0.05,P=0.032<0.05).There was no significant difference in weight loss between the Chinese medicine +TACE group after treatment and before treatment(P=0.962 > 0.05).After treatment,liver function of the Chinese medicine group and the Chinese medicine +TACE group showed no significant improvement compared with that before treatment(P=0.205>0.05,P=0.872>0.05).The scores of hepatocellular carcinoma related symptoms in the TCM +TACE group were lower after treatment than before treatment,and the difference was statistically significant(P=0.017<0.05).Conclusion:1.The half-year and 1-year survival rates of vermiculite Xiaoji prescription in the treatment of some special hepatobiliary damp-heat type advanced liver cancer were 51.72% and 31.03%,respectively.This prescription can be used as an effective supplement for the treatment of advanced liver cancer.2.The half-year and 1-year survival rates of vermiculite Xiaoji Prescriptions combined with TACE in the treatment of hepatobiliary damp-heat advanced liver cancer were 75.00% and 62.50% respectively.The combined application can improve the KPS score of liver cancer patients after TACE and improve the clinical symptoms related to liver cancer.