| Background and Aim:The population of diabetic patients in my country is huge,and the number of people with prediabetes or other diabetes risk factors continues to increase,and the epidemic situation is more severe.The 2020 national epidemiological survey shows that the prevalence of diabetes in China is 12.8%,and the prevalence of prediabetes is 35.2%,so it is particularly important to intervene in patients with diabetes at an early stage.Studies have shown that zinc supplementation has good early blood sugar control in patients with diabetes,but the results of various studies are not uniform.Therefore,this paper conducted a meta-analysis of related literature to systematically evaluate the effect of zinc supplementation on the control of blood sugar and blood lipids in patients with diabetes.Prevention and early treatment of people with diabetes provide the latest evidence.Method:Search in China National Knowledge Infrastructure(CNKI),Wanfang Database,VIP Chinese Sci-Tech eriodical Full-Text Database(VIP),Pub Med database,Web of Science database until January 1st 2022 Chinese and English literature on the effect of zinc supplementation on the control of blood sugar and blood lipids in patients with diabetes.The literature was screened strictly according to the inclusion and exclusion criteria,the Cochrane risk bias assessment tool was used for risk assessment of the included studies,and valid data were extracted.Meta-analysis was performed on the data by Revman5.4 software.Results:(1)The effect of zinc supplementation on the Fasting Blood Glucose(FBG)level in patients with type 2 diabetes mellitus,the serum FBG level in the zinc supplementation treatment group(intervention group)was significantly higher than that in the control group,and the difference was statistically significant(SMD=-0.69,95%CI:-1.31,-0.07,P<0.05).Subgroup analysis was performed according to the sample size and treatment period,and there was no statistical significance in the sample size subgroup(P>0.05),and the subgroup with treatment period <10 weeks had a statistically significant difference(SMD=-2.06,95%CI:-3.59,-0.52,P<0.05),indicating that the intervention group has a better short-term effect.(2)The effect of zinc supplementation on the level of serum Glycosylated hemoglobin(Hb A1c)in patients with type 2 diabetes mellitus,the reduction level of serum Hb A1 c in the intervention group was higher than that in the control group,and the difference was statistically significant(SMD=-0.54,95%CI:-0.72,-0.35,P<0.05).The results of subgroup analysis showed that the sample size was greater than or equal to 60 subgroups,and the difference was statistically significant(SMD=-0.72,95%CI:-0.96,-0.47,P<0.05),the intervention group was better than the control group in reducing Hb A1 c levels;In the subgroup with a period less than 10 weeks,the difference was statistically significant(SMD=-0.91,95%CI:-1.34,-0.49,P<0.05).The short-term efficacy of the intervention group was better than that of the control group.(3)The effect of zinc supplementation on the level of serum triglyceride(TG)in patients with type 2 diabetes mellitus.The reduction of serum TG in the intervention group was higher than that in the control group,and the difference was statistically significant(SMD=-0.91,95% CI:-1.54,-0.28,P<0.05).In the subgroup with a sample size of ≥60,the difference was statistically significant(SMD=-0.72,95%CI:-0.96,-0.47,P<0.05),the intervention group decreased TG levels higher than the control group;the treatment period was less than 10 weeks in the subgroup In the group,the difference was statistically significant(SMD=-1.06,95%CI:-1.48,-0.64,P<0.05),and the short-term efficacy of the intervention group was better than that of the control group.(4)The effect of zinc supplementation on the serum total cholesterol(Total Cholesterol,TC)level in patients with type 2 diabetes mellitus,the reduction level of serum TC in the intervention group was higher than that in the control group,and the difference was statistically significant(SMD=-0.48,95%CI:-0.82,-0.14,P<0.05).In the subgroup with sample size <60,the difference was statistically significant(SMD=-1.50,95%CI:-2.64,-0.36,P<0.05);in the subgroup with treatment period <10 weeks,the difference was statistically significant(SMD=-1.50,95%CI:-2.64,-0.36,P<0.05).=-2.68,95%CI:-5.02,-0.34,P<0.05),the short-term efficacy of the intervention group was better than that of the control group.(5)The effect of zinc supplementation on serum low-density lipoprotein cholesterol(Low-Density Lipoprotein Cholesterol,LDL-C)levels in patients with type 2 diabetes,the reduction level of serum LDL-C in the intervention group was higher than that in the control group,and the difference was statistically significant(SMD=-0.70,95%CI:-1.28,-0.12,P<0.05).Subgroup analysis showed that the sample size was less than 60,and the difference was statistically significant(SMD=-1.06,95%CI:-2.08,-0.05,P<0.05);the treatment period was less than 10 weeks,and the difference was statistically significant.Significance(SMD=-2.07,95%CI:-3.82,-0.32,P<0.05).(6)There was no significant difference in the effect of zinc supplementation on serum high density lipoprotein cholesterol(HDL-C)levels in patients with type 2 diabetes mellitus(SMD=0.54,95%CI:-0.13,1.20,P>0.05).The sample size subgroup was not statistically significant(P>0.05),and the treatment period was less than 10 weeks,the difference was statistically significant(SMD=1.09,95%CI: 0.12,2.05,P=0.03).Conclusion:(1)Zinc supplementation can reduce serum FBG,Hb A1 c,TG,TC and LDL-C levels in patients with type 2 diabetes,but no significant effect on HDL-C levels was found.(2)The results of subgroup analysis according to different sample sizes and treatment cycles showed that zinc supplementation also had different changes in serum FBG,Hb A1 c,TG,TC and LDL-C levels.Serum Hb A1 c and TG levels had a significant effect.In the sample size <60 group,zinc supplementation had a significant effect on serum TC and LDL-C levels.At the same time,when the treatment period was less than 10 weeks,zinc supplementation had a significant effect on serum FBG,LDL-C and LDL-C in patients with type 2 diabetes mellitus.The levels of Hb A1 c,TG,TC,LDL-C and HDL-C were significantly affected,but no significant effect was found on the long-term efficacy. |
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