A Meta-analysis Of The Relationship Between Blood Lipids And Peripheral Neuropathy In Type 2 Diabetes Mellitus

Objective: To systematically evaluate the relationship between blood lipids and diabetic peripheral neuropathy(DPN)in type 2 diabetes patients(T2DM).Methods: PubMed,Web of Science,EMBASE,Cochrane Library,CNKI,VIP and WanFang databases were searched by computer.And we searched electronic databases for relevant acticles up to December 28,2019.Chinese and English literatures which describing the correlation between total cholesterol(TC),triglyceride(TG),High density lipoprotein(HDL),Low density lipoprotein(LDL)and DPN in T2 DM patients were collected.Two researchers independently abstracted the literature according to the inclusion criteria and exclusion criteria,evaluated the quality of literature and extracted relevant data.Data were combined and analyzed using Stata14.2.Results: This meta-analysis eventually included 32 articles with a total of 6478 participants,including 1 case-control study and 31 cross-sectional studies.30 articles described the correlation between TC and DPN,29 articles described the correlation between TG and DPN,30 articles described the correlation between HDL and DPN,and 31 articles described the correlation between LDL and DPN.There was no significant difference in TC level between DPN group and non-DPN group in T2 DM patients(SMD=0.16,95%CI:-0.05~0.38,P=0.128).After removing articles with large heterogeneity,the TC level of DPN group was higher than that of non-DPN group,and the difference was statistically significant(SMD=0.19,95%CI:0.09~0.30,P=0.000).The differences of TG(SMD=0.20,95%CI:0.06~0.35,P=0.005),HDL(SMD=-0.33,95%CI:-0.56~-0.10,P=0.004)and LDL(SMD=0.34,95%CI:0.15~0.53,P=0.000)levels between the DPN group and the non-DPN group were statistically significant in T2 DM patients.The TG and LDL levels of DPN group were significantly higher than those of non-DPN group,while the HDL level was significantly lower than that of nonDPN group.Conclusions: High levels of TC,TG,LDL and low levels of HDL may be associated with DPN in T2 DM patients.Dyslipidemia may be a risk factor for DPN in T2 DM patients.