| Purpose:Part 1: Analysis the clinical features of the Diabetic Cardiopathy(DC), explore the meanings of the clinical parameters and their correlation with DC based on syndrome differentiation of traditional Chinese medicine. Part2: Analysis the clinical treatment of DC, explore the efficiency and the safety of combination of multiplex Chinese herbs and normal medicine.Material and method: Part 1: First, cases of Endocrinology of hospitalized patients with DC were collected from Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from March, 2013 to December, 2014. Second, the patients were divided into different groups according to their ages, the course of DC Hereinafter(course), smoking status and drinking condition, glycosylated hemoglobin A1(Hb A1c), Body Mass Index(BMI)based on the principal component analysis result, blood lipids and myocardial enzymes level. Part 2: Papers about DC before Mar. 1st, 2015 were collected from databases. We analyzed the efficiency,the improvement of blood sugar and lipids, and the rejection.Results:Part 1:1 179 cases, 85 males and 94 females, were included, the average age of whom was 62.32±11.48 years old, the whose average course is 2.30±4.13 years. Among them, there were 79 smokers and 100 non-smokers, 78 drinkers and 101non-drinkers.2 Eight main components were known from principal component analysis.3 Grouped by age: age and gender: x2=14.806, P=0.005<0.05, the difference was statistically significant. Age and course: x2=14.765, P=0.064>0.05, there was no statistical significant difference. Age and lipids: F=2.432, P=0.001<0.05,the difference was statistically significant. Age and myocardial enzymes: F=2.394, P=0.002<0.05, the difference was statistically significant.4 Grouped by course: course and lipids: F=1.243, P>0.05, there was no statistically significant difference. Course and myocardial enzymes: F=1.141,P>0.05,there was no statistically significant difference.5 Grouped by smoking: smoking and lipids:F=5.829, P=0.000<0.05,there was statistically significant difference. Smoking and myocardial enzymes: F=3.597,P=0.008<0.05, the difference was statistically significant.6 Grouped by drinking: drinking and lipids: F=1.49, P=0.003<0.05, there was statistically significant difference. Drinking and myocardial enzymes: F=3.119,P=0.017<0.05, there was statistically significant difference.7 Grouped by Hb A1c: Hb A1 c and lipids: Roy’s Largest Root multivariate test method showed F=3.027, P=0.019<0.05, and there was statistically significance. Hb A1 c and myocardial enzymes: F=0.365, P>0.05, there was no significant difference between Hb A1 c and myocardial enzymes.8 Grouped by BMI: BMI and lipids: F=2.189, P=0.002<0.05, there was statistically significant difference. BMI and myocardial enzymes: Roy’s Largest Root multivariate test method showed F=2.331, P=0.058, the consequence was similar to significance level of 0.05. Effect among groups of BMI on CK: P=0.036<0.05,it could be considered the difference between BMI and lipids was statistically significant.Part 2:1 Clinical efficiency : RR=1.25, 95%CI(1.19,1.31), P<0.000001, there was statistically significant difference.2 Improvement of blood sugar: FPG: RR=-0.66, 95%CI(-0.95,-0.37), P<0.000001,there was statistically significant difference. 2h PG: RR=-0.56,95%CI(-1.74,-0.62), P<0.000001, there was statistically significant difference.Hb A1 C : RR=-0.77, 95%CI(-1.53,-0.01), P=0.05, there was statistically significant difference.3 Improvement of lipids: TC: MD=-0.70, 95%CI(-1.14,-0.26), P=0.002, there was statistically significant difference. TG: MD =-0.53, 95%CI(-0.95,-0.11), P=0.01,there was no significant difference. LDL:MD =-0.02, 95%CI(-0.58,-0.55),P=0.95,there was no significant difference. HDL:MD =0.02, 95%CI(0.08,0.32), P=0.0007,there was statistically significant difference.Conclusion:Part 1:1 The elderly people and women own a high incidence in Qi and Yin deficiency complicated with blood stasis syndrome of DC.2 Age has influence on TG and CKMB in Qi and Yin deficiency with blood stasis syndrome of DC, TG and CKMB are higher in 40- years old than in other ages.3 Smoking has influence on TG and CK in Qi and Yin deficiency complicated with blood stasis syndrome of DC. TG and CK of smokers are higher than that of non-smokers.4 Drinking has influence on TG, HDL and CK in Qi and Yin deficiency complicated with blood stasis syndrome of DC, TG and CK are higher than non-smokers, the HDL is lower than non-smokers.5 Hb A1 c has influence on LDL in Qi and Yin deficiency complicated with blood stasis syndrome of DC. LDL is higher in 6.5%￡Hb A1c<7.0% group than in others.6 BMI has influence on TC, TG, HDL, CK in Qi and Yin deficiency complicated with blood stasis syndrome of DC. TC is higher in BMI<23kg/m2 group than those in BMI325 kg/m2, while TG and HDL are lower.Part 2:1 Combination of multiplex Chinese herbs and normal medicine can improve the clinical efficiency.2 The improvement of FPG, 2h PG, TC and HDL are significantly better in the combination of multiplex Chinese herbs and normal medicine group. The improvement of Hb A1 c of combination of multiplex Chinese herbs is better.Combination of multiplex Chinese herbs shares equal improvement of LDL.3 Combination of multiplex Chinese herbs and normal medicine are of high safe level. |
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