Relationship Between Body Mass Index And Neuron-specific Enolase Level In Type 2 Diabetic Patients

Objective: To explore the relationship between body mass index and neuron-specific enolase(NSE)levels in patients with type 2 diabetes(T2DM).Methods: From 2017 to 2018,408 T2 DM patients who received treatment in the fourth Hospital Affiliated to China Medical University were enrolled,And all from the Department of Endocrinology inpatient ward.T2 DM patients were classified into underweight diabetic group(DM-UW group),diabetes with normal weight group(DM-NW group),overweight diabetic group(DM-OW group)and obesity diabetic group(DM-OB group)according to BMI.The general clinical data of the subjects were obtained,and the blood glucose,blood lipid,NSE and other laboratory values were detected,and the insulin resistance index(HOMA-IR)was calculated.Comparison of study indicators including NSE levels among the four group.The correlation between NSE level and each index was obtained by Pearson correlation analysis,and the influencing factors of NSE level were obtained by multivariate linear regression analysis.Results: 1.In DM-UW,DM-NW,DM-OW and DM-OB groups,the levels of NSE decreased in turn(p<0.05).2.The results of correlation analysis showed that NSE levels were negatively correlated with BMI,fasting insulin(FINS),and insulin resistance index(HOME-IR),and positively correlated with high density lipoprotein(HDL-C)(p<0.05).3.Taking NSE as dependent variable,the results obtained by multivariate linear regression analysis show that BMI is an independent influencing factor of NSE level(p<0.05).Conclusion: The NSE level of type 2 diabetes patients decreases with the increase of BMI.BMI has a significant impact on NSE,The influence of BMI is considered in the interpretation of NSE results to reduce misdiagnosis rate and missed diagnosis rate.