Correlation Analysis Of Diabetic Retinopathy,inflammatory Factors And Complement

Objective: To detect the effect of different levelts of plasma interleukin-6(IL-6),interleukin-8(IL-8),insulin-like growth factor-1(IGF-1),vascular endothelial growth factor(VEGF)and plasma complement C3 、 C4 on different severity of diabetic retinopathy(DR)of type 2 diabetes(T2DM),provides a theoretical basis for the pathogenesis of DR.Material and methods: A total of 98 patients from the Department of Endocrinology,Shaanxi Provincial People’s Hospital from July 2020 to june 2021 were selected for fundus examination and divided into 5 groups according to the international clinical grading standard of diabetic retinopathy.Studies were performed in 30 patients with type 2 diabetes,23 cases of mild non-proliferative(NPDR),15 cases of moderate non-proliferative(NPDR),15 cases of severe non-proliferative(NPDR),and 15 patients with hyperplasia DR.Method: Collect general information,patient age,gender,medical history.collect intravenous blood to detect plasma fasting glucose(FBG),postprandial blood glucose(PBG),blood red protein(Hb A1-C),total cholesterol(TC),Triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density cholesterol value protein(HDL-C),creatinine(CR),(angiometric factor)VEGF,promote(insulinous growth factor)IGF-1,and Inflammatory correlation indicators(IL-6,IL-8,CRP,red blood cell settlement rate(RSR),and the levels of complement C3、C4,、C1q.The results were statistically analyzed by SPSS18.0 software.Results:1.Course of disease,diabetic nephropathy,FBG,PBG,Hb A1 c,complement C3,complement C1 q,IL-8,creatinine,ESR of five groups is significantly different(P <0.05).No significant differences were found among gender,diabetes peripheral vascular disease,diabetes peripheral neuropathy,systolic pressure,diastolic pressure,LDL-C,HDL-C,TG,fasting insulin,HOMA-IR,IGF-1 and VEGF of five groups.2.Pearsonrelated coefficient comparison shows that The complement C3 and VEGF are negatively correlated.The complement C3 and complement C4 are positively correlated.Complement C4 and IGF-1 positively correlated.IL-6 and creatinine,blood sink,Hb A1 C,age are positive correlation.IL-8 and TG have positive correlation.Blood and creatinine show positive correlation.Complement C1 q and ESR,complement C4,LDL-C,HDL-C,TC,age are positive correlation.3.Multi-logistic regression analysis DR risk factor,model 1: FBG,2 hours after meal,HBA1 C,IGF-1,and inflammatory related indicators IL-8,complement C3,C4,C1 q,cholesterol were included and analysed.Using entry method to analyze it is showed that FBG、PBG、and TC are mild NPDR risk factor.model 2: PBG incorporation of FBG,PBG,HBA1 C,VEGF,IGF-1,and inflammation related indicators(IL After-6,IL-8,RSR),complement C3,C4,C1 q were included and analysed.Using step-by-step forward method,it is futher showed that complement C1 q is a moderate NPDR risk factor,glycated hemoglobin and complement C1 q are severe NPDR risk factors.Conclusions: 1.The higher the levels of IL-6 and IL-8 in the plasma of patients with diabetic retinopathy,the more severe the non-proliferative retinopathy.2.The higher the level of complement C3 and C1 q in the plasma of patients with diabetic retinopathy,the more severe the non-proliferative retinopathy.The increase of complement C1 q in plasma is a risk factor for moderate to severe non-proliferative retinopathy.