| ObjectiveTo observe the clinical effect and bone metabolism of Qigu capsule combined with PKP on postmenopausal OVCF with liver and kidney deficiency,and explore its role and advantages in the treatment of this disease.MethodsFrom January 2020 to January 2021,76 cases of postmenopausal osteoporotic vertebral compression fractures(OVCF)with liver and kidney deficiency were randomly divided into two groups:(1)control group: PKP + calcium acetate granules + calcitriol capsules;(2)experimental group: Qigu capsules were added to the control group.The course of treatment of the two groups was 1 month and 1 course of treatment.After 1 course of treatment,they were suspended for 2 days and treated for 6 courses.The VAS score,JOA score(Japanese Orthopaedic Association evaluation treatment score),TCM symptom score,bone mineral density and bone metabolic markers were observed before operation,1 week,3 months and 6months after operation.The number of new fractures was followed up 12 months after operation,and relevant statistical analysis was conducted.Results1.General data: there was no significant difference in age,course of disease,distribution of injured vertebrae,VAS score,JOA score,bone mineral density,osteocalcin(OC),β-Cross Laps,total PINP and TCM syndrome score between the two groups before operation(P > 0.05).2.VAS score: after treatment,the observation time points of the two groups were significantly lower than those before operation,the difference was statistically significant(P <0.05).One week after operation,there was no significant difference between the two groups(P > 0.05).Three months and six months after operation,the VAS score of the experimental group was significantly lower than that of the control group,and the difference was statistically significant(P < 0.05).It showed that the two groups had curative effect in relieving pain.In the short term,there was no significant difference between the two groups,but with the extension of treatment time,the experimental group was significantly better than the control group.3.JOA score: after treatment,the observation time points of the two groups were significantly higher than those before operation,and the difference was statistically significant(P < 0.05).There was no significant difference between the two groups at 1 week after operation(P > 0.05).At 3 and 6 months after operation,the JOA score of the experimental group was significantly higher than that of the control group(P < 0.05),In the short term,the difference between the two groups was not significant,but with the extension of treatment time,the index of lumbar function recovery in the experimental group was more obvious than that in the control group,and the more ideal the functional recovery was.4.Bone mineral density level: after treatment,the bone mineral density of the two groups was higher than that before operation,and the difference was statistically significant(P <0.05).At 6 months after operation,the BMD of the experimental group was significantly higher than that of the control group(P < 0.05).The results showed that the improvement of BMD in the experimental group was better than that in the control group.5.Bone metabolism level: after treatment,the bone formation markers(OC,total PINP)of the two groups were higher than those before operation,and the bone resorption markers(β-Cross Laps)were lower than those before operation,the difference was statistically significant(P < 0.05).At 6 months after operation,OC and total PINP in the experimental group were significantly higher than those in the control group,and β-Cross Laps in the experimental group were significantly lower than those in the control group(P < 0.05).The results showed that the regulation of bone metabolism in the experimental group was better than that in the control group.6.After treatment,the total effective rate of the experimental group was 91.7%,and that of the control group was 83.3%;the effective rate of the clinical efficacy evaluation of the experimental group was 88.9%,and that of the control group was 77.8%,the difference was statistically significant(P < 0.05),indicating that the clinical efficacy of the experimental group was better than that of the control group.7.New fractures: 12 months after operation,the new fracture rate of the two groups was14.4%.There were 2 cases of new fractures in the experimental group and 9 cases of new fractures in the control group.The difference between the two groups was statistically significant(P < 0.05),indicating that the new fracture rate of the experimental group was significantly lower than that of the control group.ConclusionsQigu capsule combined with PKP is more effective than conventional postoperative treatment in postmenopausal OVCF patients with liver and kidney deficiency;It can reduce the low back pain,restore the lumbar function,reduce the new fracture rate,regulate the level of bone metabolism,improve the quality of life,and is safe and simple,which is worthy of clinical application. |
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