| Objective:More and more attention has been paid to the metabolic syndrome(Met S)in patients with schizophrenia.Not all patients with chronic schizophrenia who are treated with a single atypical antipsychotic drug have such problems.BDNF can inhibit appetite,reduce body weight and affect energy consumption.It has an effect on glucose and lipid metabolism and is closely related to the occurrence of metabolic syndrome.With cross-sectional design,this study included patients with chronic schizophrenia who were regularly treated with atypical antipsychotic drugs,and compared the differences of glucose and lipid metabolism related indexes and related factors between the two groups of Met S and non-Met S patients with schizophrenia,and further compared the gender differences of each variable.In addition,candidate loci BDNF(rs11030104,rs6265)were selected for genotyping to explore the genetic risk of schizophrenia complicated with Met S.Methods:311 patients with schizophrenia who met the exclusion criteria were recruited.The general and demographic characteristics were collected by self-designed question scale.The height,weight,waist circumference,abdominal circumference and hip circumference of the patients were measured.Moreover,the waist-hip ratio and body mass index were calculated.Also,the metabolic syndrome related indexes and some biochemical indexes were detected,including GLU、TP、ALB、TG、CHOL、HDL、LDL、T3、T4 and TSH.According to the inclusive and exclusive criteria of Met S,the patients were divided into two groups: schizophrenia with Met S group and non-Met S group.The incidence was calculated and the differences of each variable between groups were compared.The genomic DNA of the patients were extracted to detect the gene polymorphisms of candidate gene BDNF(rs11030104,rs6265).The alleles and genotypes between the Met S group and non-Met S group were compared.Results:1.In this study,the prevalence of Met S in patients with schizophrenia was 32.2%.Female patients with Met S was significantly higher than that of men.There were significant differencesbetween Met S patients and non-Met S patients in body weight,BMI,waist-to-hip ratio,TG,systolic blood pressure,diastolic blood pressure,LDL,CHOL and GLU.The body weight,BMI,TG,diastolic blood pressure and LDL could pass Bonferroni correction.Inaddition,logistics regression analyses showed that sex,waist-to-hip ratio and BMI were independent risk factors for schizophrenia complicated with Met S.2.In male patients,the body weight,BMI,TG,LDL and CHOL of the patients with metabolic syndrome were significantly higher than those of the patients without metabolic syndrome.Moreover,the body weight,BMI,TG and LDL could pass the Bonferroni correction.In female patients,patients with Met S had significant increases in body weight,BMI,waist-hip ratio,systolic blood pressure,diastolic blood pressure,TG,GLU and other indexes.Moreover,body weight,BMI,waist-to-hip ratio,systolic blood pressure,diastolic blood pressure and TG could pass the Bonferroni correction.3.There was significant difference among BDNF rs11030104 AA,GA and GG genotypes of patients complicated with Met S.There was significant difference among BDNF rs6265 CC,CT and TT genotypes of patients complicated with Met S.4.In female patients,there were significant differences among the genotypes of BDNF rs11030104 and BDNF rs6265 polymorphisms in those combined Met S.Conclusion:1.In the chronic schizophrenic patients taking a stable dose of atypical antipsychotics,the patients with Met S are highly prevalent.Sex,waist-to-hip ratio and BMI are independent risk factors of schizophrenia complicated with Met S.2.The prevalence of female patients with Met S is higher than that of male patients.Moreover,there are differences in some related factors of Met S among different genders of schizophrenia patients.3.BDNF rs11030104 and rs6265 are closely related to Met S in female patients with chronic schizophrenia. |
