| Objective: This study analysis of severe traumatic brain injury(s TBI)in patients with massive bleeding when the body change trend of clotting factors,explore machine adopt joint platelet cryoprecipitate infusion of blood coagulation function in patients with severe traumatic brain injury bleeding,for patients with severe traumatic brain injury bleeding heavily provided a reference for clinical treatment,improve patients with s TBI clinical cure rate.Methods: In this study,102 patients with s TBI who met the inclusion criteria were admitted to the Second Hospital of Tianjin Medical University from January 2017 to December 2018.The clinical blood data of 102 patients with s TBI were collected and divided into group A with single platelet transfusion(36 cases in total).A total of 36 patients in group B were treated with cold precipitation.A total of 30 patients were treated with platelet and cryoprecipitate in group C.The data of PT and INR value,TT,APTT,Plt,FIB in 102 s TBI patients within 1h before and 24 h after the transfusion of blood products were collected.The hemostasis time after transfusion of corresponding blood products,the infusion volume of single platelet(Plt),cryoprecipitate,and red blood cell suspension(RBC)in the 102 s TBI patients were collected,and the effective hemostasis rate was obtained within 24 h.Double entry of statistical data into excel to create the database of this study.The differences of platelet(Plt),fibrinogen(FIB),thrombin time(TT),activated partial thrombin time(APTT),prothrombin time(PT)and INR before and after transfusion of blood products were compared among the three groups.The differences of platelet(Plt),fibrinogen(FIB),thrombin time(TT),activated partial thrombin time(APTT),prothrombin time(PT)and INR before and after transfusion of corresponding blood products were compared in the three groups.The hemostasis time,infusion volume of platelets(Plt),cryoprecipitation,and red blood cell suspension(RBC)in the three groups after transfusion of corresponding blood products were compared and analyzed.The difference of the effective hemostasis rate within 24 hours was statistically significant.SPSS 20.0 statistical software was used for analysis,and the rate of count data was expressed as(%),while measurement data was expressed as(x ±s).Corresponding statistical data were analyzed,and P<0.05 was considered as statistically significant difference.Results: 1.Comparison of platelet(Plt),fibrinogen(FIB),prothrombin time(PT)and INR,thrombin time(TT),activated partial prothrombin time(APTT),within 1h before infusion was not statistically significant(P > 0.05).2.Plt and FIB of patients in group C(combined infusion group)within 24 h of blood product infusion were all higher than that within 1h before infusion,and coagulation indexes of TT,APTT and PT were all lower than that within 1h before infusion.Only Plt and FIB were statistically significant before and after infusion in group A(P<0.05),FIB、 PT、TT and APTT were statistically significant before and after infusion in group B(P<0.05),and coagulation indexes such as Plt、FIB、TT、APTT、PT and INR were statistically significant before and after infusion in group C(P<0.05).3.Compared with patients in group A and B,patients in group C had shorter hemostasis time,lower infusion volume of suspended red blood cells(RBC),and higher effective hemostasis rate within 24 hours,showing more obvious advantages(P<0.05).Conclusion: 1.Combined infusion of platelets and cryoprecipitate is more effective than single infusion of platelets and cryoprecipitate in improving the coagulation system function of patients with s TBI with massive blood loss,and has higher clinical application value.2.For patients with massive blood loss due to s TBI,combined infusion of monoplectic platelets and cryoprecipitate has obvious advantages over platelet transfusion or cryoprecipitate alone in terms of hemostasis time,infusion volume of suspended RBC,effective hemostasis rate within 24 hours,and clinical efficacy,with higher clinical application value. |
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