Clinical Study Of Xinpuyin No.2 Combined With Omeprazole In The Treatment Of Helicobacter Pylori-related Gastric Disease With Spleen And Stomach Damp-heat Syndrome

Objective:Through clinical controlled studies,observe the Hp eradication rate,the improvement of TCM symptoms and the safety in the treatment of Helicobacter pylori(Hp)-related gastric disease with spleen and stomach damp-heat syndrome of Xinpuyin No.2 combined with omeprazole.To evaluate the therapeutic effect of Xinpuyin No.2 combined with omeprazole on the treatment of Hp-related gastric disease with spleen and stomach damp-heat syndrome,aiming to explore a safe and effective new treatment plan for Hp without antibiotics,and provide more options for clinical treatment.Methods:A total of 64 patients who met the research standards in Nanjing Hospital of Traditional Chinese Medicine were selected and randomly divided into a treatment group and a control group,each with 32 patients.The treatment group was treated with Xinpuyin No.2 combined with omeprazole,and the control group was treated with a standard triple regimen(omeprazole+clarithromycin+amoxicillin).The course of treatment was 14 days.The 13C breath test was performed 4-8 weeks after the drug was stopped to observe the Hp eradication rate,and the patients’ TCM symptoms were evaluated by points before and after treatment.Record the patient’s adverse reactions during the medication.Results:(1)In terms of eradication rate,the eradication rate of the treatment group was 68.97%,and that of the control group was 70.00%.According to the chi-square test,P>0.05,there was no statistical difference in the eradication rate between the two,indicating that the eradication effect was equivalent;(2)In terms of TCM symptom scores,P>0.05,there was no statistically significant difference in the improvement of dry mouth and bitter mouth,loose stools or sticky symptoms in the control group before and after treatment.In addition,the scores of the two groups before and after treatment are statistically different(P<0.05),suggesting that the two treatment options can alleviate the patients,symptoms of TCM.In the comparison of TCM symptoms after treatment,the two have statistically significant differences(P<0.05)in gastric fullness,dry mouth,bitter mouth,belching,heavy limbs,and loose stools or sticky stools.The therapeutic effect of the treatment group is better than the control.In the gastric cavity pain,odor in the mouth,loss of appetite,nausea and vomiting,there was no statistical difference between the two(P>0.05),indicating that the treatment effect was equivalent;(3)In the evaluation of the curative effect of TCM syndromes,in the treatment group,1 case was cured,20 cases were markedly effective,7 cases were effective,and 1 case was ineffective.The total effective rate was 96.55%,In the control group,4 cases were markedly effective,19 cases were effective,and 7 cases were ineffective.The total effective rate was 76.67%.After testing,P<0.05,there was a statistical difference in the efficacy between the two groups,and the treatment group was better than the control group;(4)In terms of adverse reactions,the incidence of adverse reactions in the treatment group was 6.9%,and the incidence of adverse reactions in the control group was 30%.After testing,P<0.05,there is a statistical difference in the incidence of adverse reactions between the two,and the safety of the treatment group is higher than that of the control group.Conclusion:Xinpuyin No.2 combined with omeprazole in the treatment of patients with Hp infection with spleen and stomach damp-heat syndrome is equivalent to standard triple therapy in terms of Hp eradication rate,and the improvement rate of TCM symptoms is better than the standard triple therapy,and it has higher safety,It suggests that Xinpuyin No.2 has a better anti-Hp effect,and provides new directions and ideas for eradicating Hp under the environment of increasing antibiotic resistance.