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Analysis Of The Relationship Between Metabolic Syndrome And The Pathological Grade And Stage Of Bladder Cancer

Posted on:2022-04-12Degree:MasterType:Thesis
Country:ChinaCandidate:Y S LeiFull Text:PDF
GTID:2494306329486534Subject:Clinical Medicine
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Objective:To analyze the relationship between metabolic syndrome and the pathological findings in patients with bladder cancer.Methods:We retrospectively analyzed the clinical data of 295 patients with bladder cancer from the department of urology,the first Bethune hospital of Jilin university from July 2017 to July 2020.All the patients are diagnosed with bladder cancer for the first time and then accepted the surgery treatment.Age,sex,weight,height,body mass index,blood pressure,blood glucose,triglyceride,high density lipoprotein cholesterol,pathological grade and stage were evaluated respectively.The pathological grade was determined according to the 2004 World Health Organization grading system.And the 2017 American Joint Committee on Cancer TNM staging system was used,with Ta and T1 tumors accepted as lower stage and T2,T3 and T4 tumors as higher stage bladder cancer.The relationship between metabolic syndrome and the pathological grade and stage were analyzed by using T-test,Chi-square test,Mann-Whitney U test and Binary logistic regression analysis.Results:Among the total of 295 patients analyzed in our study,there were 232 males and 63 females.Bladder cancer with and without metabolic syndrome was found in 64 and 231 patients respectively.Tumor pathological stage were determined high stage(T2,T3 and T4)in 47 patients,and 74 patients with high tumor pathological grade.The statistical analysis results are as following:(1)The body mass index,fasting blood glucose,blood pressure and triglyceride in patients with MetS are significantly higher than those of patients without MetS(P<0.05),and the HDL-c in patients with MetS is significantly lower than those of patients without MetS(P<0.05).(2)The proportion of high pathological grade and stage in patients with MetS are much higher than those of patients without MetS(P<0.05).(3)The proportion of high pathological grade in patients with bladder cancer combined with hyperglycemia or hypertension is much higher than those of patients without hyperglycemia or hypertension(P<0.05).The proportion of high pathological grade in patients with bladder cancer combined with hyperglyceridemia is much lower than those of patients without hyperglyceridemia(P<0.05).The proportion of high pathological stage in patients with bladder cancer combined with hyperglycemia is much higher than those of patients without hyperglycemia(P<0.05).(4)The univariate binary logistic regression analysis shows that,metabolic syndrome is a risk factor for high pathological grade and stage of bladder cancer(P=0.001,OR=5.399,95%CI 2.036-14.318;P=0.014,OR=2.349,95%CI 1.189-4.643).The multivariate binary logistic regression analysis shows that,hyperglycemia and hypertension are risk factors for high pathological grade of bladder cancer(P=0.017,OR=3.37,95%CI 1.245-9.127;P=0.036,OR=1.946,95%CI1.044-3.627),and hyperglycemia is also a risk factor for high pathological stage of bladder cancer(P=0.003,OR=2.881,95%CI 1.426-5.820).(5)Metabolic syndrome is a risk factor for high pathological grade and stage of bladder cancer in male patients(P=0.001,OR=8.342,95%CI 2.448-28.425;P=0.018,OR=2.549,95%CI 1.172-5.545),But there is no relationship between metabolic syndrome and the pathological grade and stage of bladder cancer in female patients.Conclusions:(1)Metabolic syndrome is significant associated with the pathological grade and stage in patients with bladder cancer.(2)Hyperglycemia and hypertension are risk factors for high pathological grade of bladder cancer,and hyperglycemia is also a risk factor for high pathological stage of bladder cancer.(3)Metabolic syndrome is a risk factor for high pathological grade and stage of bladder cancer in male patients,But there is no relationship between metabolic syndrome and the pathological grade and stage in female patients.
Keywords/Search Tags:Metabolic Syndrome, Bladder Cancer, Pathological Grade, Pathological Stage
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