| OBJECTIVE:To treat the condition of rheumatoid arthritis and its associated anxiety and depression with Xiaoyaosan combined with Iguratimod,and objectively evaluate the method of regulating liver for rheumatoid arthritis patients,further explore the pathogenesis of rheumatoid arthritis in Chinese medicine,and explore the Chinese medicine treatment of rheumatoid arthritis in the era of biological agents.METHODS:All observations were from the outpatients of the Department of Rheumatology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine from April 2017 to December 2017.A total of 66 patients who met the inclusion criteria were enrolled and randomly divided into the experimental group(Chinese medicine combined with biological agent treatment group)31 cases and the control group(Western medicine treatment group)35 cases.The experimental group was treated with traditional Chinese medicine Xiaoyao Powder and Totuzumab and the recommended RA for the treatment of DMARDs drug MTX.The control group was treated with Western medicine alone.After 24 weeks of treatment,the patient’s efficacy and mood improvement were compared before and after treatment.Using the internationally recognized DAS28 disease activity,DAS28 compliance rate,ACR20 50 70 compliance rate to evaluate the patient’s condition improvement;using the patient-based outcome report scale to assess the patient’s self-evaluation of the condition;using the self-rating anxiety scale,self-evaluation of depression Table,fatigue self-rating scale to assess the improvement of patients’ mood;at the same time,assess the changes of patients’laboratory indicators and safety indicators,so as to comprehensively evaluate the improvement effect of traditional Chinese medicine combined with Iguratimod on the condition and mood of RA patients.RESULTS:Baseline index comparison showed that there was no significant difference in age,gender,disease duration,activity index and emotional index between the two groups before and after treatment(p>0.05),indicating that the follow-up efficacy can be compared between the two groups.After 24 weeks of treatment,patients were comprehensively evaluated:1.The disease activity of both groups was significantly improved.The DAS28 compliance rate,ACR20 50 70 compliance rate and laboratory inflammatory index were significantly improved compared with before treatment(p<0.05).The comparison between the two groups found that the Chinese medicine combined with Iguratimod treatment group was significantly better than the Western medicine treatment(P<0.05).2.The self-evaluation of the two groups was improved compared with that before treatment(p<0.05).The comparison between the groups showed that the self-evaluation of the patients in the experimental group improved more significantly(p<0.05).3.The scores of anxiety,depression and fatigue were significantly improved in the two groups(p<0.05),and the improvement of anxiety in the Chinese medicine combined with the Iguratimod group was significantly higher than that in the western medicine group(p<0.05).At the same time,the Chinese medicine combination group was more significant in the improvement of depression and fatigue than the western medicine treatment group(p<0.01).No adverse reactions occurred in either group during the study period.Conclusion:Through clinical observation,it is found that the simple Western medicine treatment group and the traditional Chinese medicine combined with the Iguratimod treatment group have satisfactory therapeutic effects in improving the disease activity and controlling the progress of the disease.At the same time,the treatment of Xiaoyao Powder plus toxinizumab is better.Improve the patient’s mood and physical sensation,and better improve the patient’s self-discipline score and quality of life.The two groups of patients played a similar role in drug safety. |
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