Effects Of Second-hand Smoke Exposure Onpregnacy Outcomes In Patients With Ploycystic Ovary Syndrome

Objective:The effects of secondhand smoke exposure on patients with polycystic ovary syndrome were investigated by analyzing reproductive endocrine,glycolipid metabolism,clinical phenotype,pregnancy and neonatal outcomes.Method:This study was based on a large sample,multicenter,and randomized controlled trial,"effects of acupuncture and clomiphene on the survival rate of women with polycystic ovary syndrome".By referring to the smoking history of both husband and wife of 1000 subjects,271 patients without second-hand smoke exposure and 229 patients exposed to second-hand smoke environment were screened out.For the degree of second-hand smoke violence,patients were divided into the high-exposure group and low-exposure group according to their husbands’ smoking status(whether smoking is more than 10 cigarettes per day).The differences in reproductive endocrine,glycolipid metabolism,clinical phenotype,birth and neonatal outcomes were analyzed.SAS 8.3 statistical software was used for statistical analysis.Result:1.In the baseline characteristics of patients with PCOS and her husband in various indicators of semen,SHS exposure group and the SHS exposure group and low SHS exposure group and the SHS exposure group and higher SHS between exposure group and the SHS exposure group were no significant difference(P>0.05).2.In sex hormones,free testosterone index in SHS between exposure group and the SHS exposure group had extremely significant difference(P<0.01),total testosterone and sex hormone binding globulin(SHBG)between the SHS exposure group and the SHS exposure group had significant difference(P<0.05);There were significant differences in total testosterone,free testosterone index,free testosterone,testosterone/estradiol and sex hormone globulin between high SHS exposure group and non-shs exposure group(P<0.0 1).3.In the indicators glucolipid metabolism,SHS exposure group and the SHS exposure group and low SHS exposure group and the SHS exposure group and high SHS between exposure group and the SHS exposure group were no significant difference(P>0.05).4.In the clinical phenotype,there was a significant difference in metabolic syndrome between SHS exposure group and non-shs exposure group(P<0.05);Hairy,acne,months after less and amenorrhea polycystic ovary state index of the four,the SHS exposure group and the low total SHS exposure group,the SHS exposure group and the SHS exposure group and the SHS between exposure group and high SHS exposure group were no significant difference(P>0.05).5.In the ovulation and pregnancy outcomes,conception rate between SHS exposure group and the SHS exposure group had significant difference(P<0.05),high conception rate in SHS between exposure group and the SHS exposure group is more significant difference compared with low exposure group(P=0.05).Although there was no significant difference between the clinical pregnancy rate and the live birth rate between the SHS exposure group and the non-shs exposure group(P>0.05),there was a significant downward trend.There was no significant difference in ovulation rate between the high SHS exposure group and the non-shs exposure group(P>0.05),but there was a significant tendency to decrease.6.In neonatal outcomes,there was no significant difference between SHS exposure group and non-shs exposure group,low SHS exposure group and non-shs exposure group,and high SHS exposure group and non-shs exposure group(P>0.05).Conclusion:1.Secondhand smoke exposure increased serum androgens in patients with polycystic ovary syndrome,but did not aggravate the clinical manifestations of hyperandrogenemia.2.Secondhand smoke exposure reduces pregnancy rate,clinical pregnancy rate and live birth rate of patients with polycystic ovary syndrome.